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Cloned stem cells

By | May 1, 2001

Pluripotent stem cells hold promise for transplantation therapy to treat degenerative diseases, but isolating a patient's stem cells may pose a technical limitation. In the April 27 Science, Wakayama et al. describe the application of cloning to generate embryonic stem (ES) cells (Science 2001, 292:740-743). The authors used nuclei from adult-derived somatic donor cells of five different strains of mice to produce cloned blastocysts. These were then used to derive 35 different nuclear transfer E

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Deficient domain protein reveal pathway for cardiomyopathy

By | May 1, 2001

associated LIM gene destabilizes actin anchorage sites in cardiac muscle.

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Genetic susceptibility to infertility

By | May 1, 2001

Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.

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NAS election results

By | May 1, 2001

The US National Academy of Sciences today announced the election of 72 new members.

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Bcl-3 gene is involved in T cell survival

By | April 30, 2001

Immunological adjuvants may improve survival of activated T cells via induction of the Bcl-3 gene.

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Chimp controversy

By | April 30, 2001

Sensitive PCR analysis of vaccine samples refutes the controversial hypothesis that the AIDS epidemic began with a contaminated oral polio vaccine.

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Neonatal markers for autism

By | April 30, 2001

Despite intense speculation about a possible link between the rates of administration of the MMR vaccine and an increase in the incidence of autism, the underlying biochemical mechanisms of the condition remain unknown. In May Annals of Neurology Karin Nelson and colleagues from the National Institute of Neurological Diseases and Stroke, Bethesda, US show that children with autism have an increase in certain neuropeptides and neurotrophins in their peripheral blood from the first days of life.Ne

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Amygdala arrays

By | April 27, 2001

The complex anatomical organization and cellular heterogeneity of the mammalian brain may complicate the interpretation of transcriptome analysis of brain tissues. In the April 24 Proceedings of the National Academy of Sciences, Zirlinger et al. describe how in situ hybridization studies can improve microarray analysis of the brain (Proc Natl Acad Sci USA 2001, 98:5270-5275). The authors compared the expression of over 34,000 genes using Affymetrix GeneChip oligonucleotide arrays with RNA from f

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Early detection of breast cancer by methylation-specific PCR

By | April 27, 2001

A combination of cytology and methylation markers in breast-duct fluid could be useful for detecting breast cancers that are missed by mammograms.

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how clear is the crystal ball?

By | April 27, 2001

, and a recent report from the UK's House of Commons Science and Technology Committee raise serious concerns about the widespread use of predictive genetic testing.

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