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January 8, 2001|
Histone modifications are required to gain access to DNA sequences within the tightly compacted genome and enable gene transcription. It has been proposed that acetylation of the amino-terminal tails of the core histones within the nucleosome particle is critical for activating transcription. In the December Genes and Development, Nowak and Corces suggest that histone phosphorylation may play a greater role than acetylation in gene induction (Genes Dev 2000, 14:3003-3013). They studied the he