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cancer, genetics & genomics

Book Excerpt from p53
Sue Armstrong | Mar 31, 2015 | 4 min read
In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.
Focus on Sex
Molly Sharlach | Dec 28, 2014 | 3 min read
In 2014, new research findings and guidelines brought increased attention to biological differences between males and females.
The Origins of Oversized Chromosomes
Molly Sharlach | Nov 12, 2014 | 2 min read
Researchers reconstruct the formation of the giant neochromosomes that contribute to some cancers.
Week in Review: June 9–13
Tracy Vence | Jun 13, 2014 | 3 min read
Ancient apoptotic pathway connects humans to coral; lab-grown, light-sensing retinal tissue; tracking cancer with synthetic phospholipids; diving deep into the lung microbiome
Genome Digest
Tracy Vence | Jun 11, 2014 | 4 min read
What researchers are learning as they sequence, map, and decode species’ genomes
Week in Review: May 19–23
Tracy Vence | May 23, 2014 | 3 min read
Sperm-sex–sensing sows; blocking a pain receptor extends lifespan in mice; stop codons can code for amino acids; exploring the tumor exome
Making Sense of the Tumor Exome
Kerry Grens | May 18, 2014 | 3 min read
An algorithm can pick out biologically and clinically meaningful variants from whole-exome sequences of tumors.
IDing Cancer with 3-D Genomics
Tracy Vence | May 7, 2014 | 1 min read
In a proof-of-principle study, scientists show that the three-dimensional shape of a cancer cell genome can reliably classify subtypes of human leukemia.
Opinion: Overcoming Cancer’s Complexities
Daniel S. Kapp, David Rubenson, and Beverly Mitchell | Apr 11, 2014 | 4 min read
Considering “targeted therapeutics” in the face of intra-patient heterogeneity. 
Week in Review: April 7–11
Tracy Vence | Apr 11, 2014 | 3 min read
Stress and telomere length in children; osmotic channel protein identified; amoeba nibbles, then kills cells; amphetamine and mental disorder risk; news from AACR
Obesity Complicates Colorectal Cancer
Tracy Vence | Apr 9, 2014 | 2 min read
Study finds that prediagnosis obesity is predictive of poor prognosis, even among patients who have a molecular marker associated with better disease outcome.
Week in Review: March 3–7
Tracy Vence | Mar 7, 2014 | 3 min read
The gene behind a butterfly’s mimicry; the evolution of adipose fins; bacteria and bowel cancer; plants lacking plastid genomes
Week in Review: January 27–31
Tracy Vence | Jan 31, 2014 | 3 min read
Stimulus-triggered pluripotency; antioxidants speed lung tumor growth; the importance of seminal vesicles; how a plant pathogen jumps hosts
Week in Review: January 13–17
Tracy Vence | Jan 17, 2014 | 3 min read
Debating the origins of placental mammals; H. pylori-human coevolution; ant, bee, and wasp queens emit similar pheromones; profiling protein expression in single cancer cells
Opinion: Calculating Cancer
Alexander (Sandy) Anderson and Robert Gatenby | Jan 6, 2014 | 3 min read
How a growing partnership between oncologists and mathematicians is moving research forward.
Cancer Pioneer Dies
Jef Akst | Dec 20, 2013 | 2 min read
Janet Rowley, who earned fame for linking chromosomal abnormalities to cancer in the 1970s, has passed away at age 88 from ovarian cancer.
Week in Review: December 2–6
Tracy Vence | Dec 6, 2013 | 3 min read
Oldest hominin DNA sequence; visualizing dyslexia; testing CRISPR; cancer and autoimmunity
Week in Review: November 18–22
Tracy Vence | Nov 22, 2013 | 4 min read
Chilly mice develop more tumors; gut bacteria aid cancer treatment; two Y chromosome genes sufficient for assisted reproduction; HIV’s “invisibility cloak”
Retracing Steps
Aimee Swartz | Nov 11, 2013 | 3 min read
Sage Bionetworks aims to show that transparency and sharing are key to ensuring research reproducibility.
Clocking Epigenetics
Abby Olena, PhD | Oct 22, 2013 | 2 min read
DNA methylation status can predict age in various human tissues, a study shows.
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