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tag histone methylation genetics genomics lncrna wildlife biology

Managing Methylation
Karen Zusi | Jan 1, 2016 | 2 min read
A long noncoding RNA associated with DNA methylation has the power to regulate colon cancer growth in vitro.
a microscope image of a rotifer
Bacterial Enzyme Keeps Rotifers’ Transposable Elements in Check
Christie Wilcox, PhD | Mar 3, 2022 | 5 min read
Jumping genes in bdelloid rotifers are tamped down by DNA methylation performed by an enzyme pilfered from bacteria roughly 60 million years ago, a study finds.
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
High-Throughput Epigenetics Analyses
Jyoti Madhusoodanan | Jan 1, 2018 | 7 min read
Emerging technologies help researchers draw mechanistic links between metabolism and epigenetic modification of DNA.
The Genetics of Society
Claire Asher and Seirian Sumner | Jan 1, 2015 | 10 min read
Researchers aim to unravel the molecular mechanisms by which a single genotype gives rise to diverse castes in eusocial organisms.
Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
Epigenetics: Genome, Meet Your Environment
Leslie Pray | Jul 4, 2004 | 10+ min read
©Mehau Kulyk/Photo Researchers, IncToward the end of World War II, a German-imposed food embargo in western Holland – a densely populated area already suffering from scarce food supplies, ruined agricultural lands, and the onset of an unusually harsh winter – led to the death by starvation of some 30,000 people. Detailed birth records collected during that so-called Dutch Hunger Winter have provided scientists with useful data for analyzing the long-term health effects of prenat
Lamarck and the Missing Lnc
Kevin V. Morris | Oct 1, 2012 | 8 min read
Epigenetic changes accrued over an organism’s lifetime may leave a permanent heritable mark on the genome, through the help of long noncoding RNAs.
CRISPR Screen Detects Functional Gene Regulation
Abby Olena, PhD | Apr 3, 2017 | 3 min read
A CRISPR-Cas9–based method probes the regulatory roles of noncoding DNA sequences.
Opinion: Engineering the Epigenome
Anna Köferle, Stefan H. Stricker, and Stephan Beck | Aug 26, 2015 | 3 min read
The use of targetable chromatin modifiers has ushered in a new era of functional epigenomics.

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