histones, epigenetics

The methodology involves modifying histones and displaying them on the cell surface for analysis.

By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

Mouse fathers whose sperm lacks the gene Kdm6a pass down altered methylation patterns to male offspring, along with a better chance of developing tumors and dying.

Regular replacement of histones in human and murine neurons is required for neuronal plasticity, a study shows.

Scientists show how roundworm daughter cells remember the histone modification patterns of their parents.

Histones stored on lipid droplets in fly embryos provide a backup supply when newly synthesized ones are lacking.

Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa

Mimicking a host-cell histone protein offers flu a sneaky tactic to suppress immune response.

Chemicals that change the way DNA is packaged could improve the effects of current antipsychotics.

Testing a central tenet of epigenetic regulation

Shiv Grewal has seen both late nights and early mornings in the lab – and connections between seemingly disparate elements that other molecular biologists might miss.

David Allis from Rockefeller University and colleagues used a biochemical pull-down assay and found that the protein WDR5, a common part of histone methyltransferase complexes, associates specifically with dimethylated H3K4 nucleosomes.

Four papers released online today detail some of the work from David Allis's group and others on chromatin remodeling.