histones, epigenetics, genetics & genomics

By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

Mouse fathers whose sperm lacks the gene Kdm6a pass down altered methylation patterns to male offspring, along with a better chance of developing tumors and dying.

Scientists show how roundworm daughter cells remember the histone modification patterns of their parents.

Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa

Shiv Grewal has seen both late nights and early mornings in the lab – and connections between seemingly disparate elements that other molecular biologists might miss.

Four papers released online today detail some of the work from David Allis's group and others on chromatin remodeling.