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tag histone modification histone methylation dna methylation ecology

Histone Methylation is Making its Mark
Brendan Maher | Jan 26, 2003 | 6 min read
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. M. Lachner et al., "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins," Nature, 410:116-20, 2001. (Cited in 202 papers) A.J. Bannister et al., "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain," Nature, 410:120-4, 2001. (Cited in 2
Profiling Human Histones
The Scientist Staff | Jul 1, 2007 | 1 min read
Some patterns of histone methylation are linked to human gene activation, and other patterns are linked to gene repression. By combining chromatin immunoprecipitation with new Solexa 1G sequencing technology, Artem Barski at the National Institutes of Health and colleagues from the University of California, Los Angeles, generated genome-wide maps for histone methylations and correlated methylation events with different levels of gene expression.1 The researchers saw differences in methy
Heritable Histones
Ruth Williams | Sep 18, 2014 | 3 min read
Scientists show how roundworm daughter cells remember the histone modification patterns of their parents.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
The Histone Code
Brendan Maher | Jan 26, 2003 | 2 min read
5-Prime | The Histone Code Courtesy of IMP/TKadletz What is the histone code? Different chemical marks, such as acetylation, methylation, or phosphorylation, are made to numerous residues on the N-terminal tails of histone proteins. Some posit that they act as readable and specific landing pads for proteins that control chromatin modeling and transcriptional regulation. The marks appear to be clustered in different regulatory groups signifying "on" and "off" portions of the genome, and som
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017 | 10+ min read
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Managing Methylation
Karen Zusi | Jan 1, 2016 | 2 min read
A long noncoding RNA associated with DNA methylation has the power to regulate colon cancer growth in vitro.
How epigenetics affects twins
Charles Choi(cqchoi@nasw.org) | Jul 6, 2005 | 3 min read
In genetically identical siblings, DNA methylation and histone acetylation correlate with age and lifestyle
DNA Methylation Declines with Age
Sabrina Richards | Jun 11, 2012 | 3 min read
Newborns carry more epigenetic markers than nonagenarians, providing clues to the mechanisms underlying aging.
Histones are everywhere
Brendan Maher | May 10, 2006 | 2 min read
Just the other day I was talking to a researcher on the phone whose work had unexpectedly intersected with nucleosome remodeling. I get the feeling it?s not an uncommon occurrence. I?ve enjoyed following the linkurl:explosion of research;http://www.the-scientist.com/article/display/23392/ on this topic in the past decade, in part because the analogies are irresistible. As the now pat intro to numerous papers on the subject says, with the sequence of the human genome at hand, scientists are lo

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