epigenetics, cancer

Researchers studying lung cancer cell lines found that chromatin remodeling underlies one type of osimertinib resistance.

A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 

In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.

A pair of new studies finds that analyzing material from a Pap smear can reveal tumor risk in distant parts of the body, potentially allowing early interventions.

A key mutation turns healing cells into cancer promoters.

The Dana-Farber Cancer Institute researcher is developing cancer therapeutics based on how the physical structure of DNA contributes to the disease.

Mouse fathers whose sperm lacks the gene Kdm6a pass down altered methylation patterns to male offspring, along with a better chance of developing tumors and dying.

Emerging technologies help researchers draw mechanistic links between metabolism and epigenetic modification of DNA.

A selection of notable quotes from the annual American Association for Cancer Research meeting

Two mutations in a gene involved in telomere extension reverse the gene’s epigenetic silencing.

A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks.

Within days of their transfer to a dish, a certain epigenetic mark vanishes from mouse cells.

A transgene designed to attract methylation to the promoter of a tumor-suppressor gene leads to tumorigenesis in a mouse model. 

Investigational drug that inhibits proteins involved with epigenetic regulation shows activity against certain blood cancers in an early-stage clinical trial.

DNA methylation status can predict age in various human tissues, a study shows.

Children with obese fathers show epigenetic changes that may affect their health.