epigenetics

An advanced multiomics solution allows researchers to predict gene expression, chromatin accessibility, and enhancer state from one DNA sample.

An analysis of almost 700 different tumors revealed that DNA methylation drives tumorigenesis just like genetic mutations do. 

A new strategy prevents reprogramming-induced epigenetic aberrations in human induced pluripotent stem cells.

Researchers studying lung cancer cell lines found that chromatin remodeling underlies one type of osimertinib resistance.

How will a new version of epigenetic clocks aimed at validating the age of people older than 100 years of age balance accuracy and anonymity?

A new study relying on DNA methylation clocks suggests that the biological age of mouse and human cells can fluctuate in response to stressful events.

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

This year’s stories highlight the expanding versatility of genetic techniques and the increasing utility of such research in all life science fields.

Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.

A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 

Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.

Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.