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image: Neoantigens Enable Personalized Cancer Immunotherapy

Neoantigens Enable Personalized Cancer Immunotherapy

By | April 1, 2017

Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

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While studying the progression of healthy cells into cancerous ones, researchers discover a way to engraft human blood cells into animals.

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image: Starvation Response Triggers Melanoma Invasion

Starvation Response Triggers Melanoma Invasion

By | April 1, 2017

Through similar mechanisms, amino acid depletion in culture and cytokine activity in the tumor microenvironment prompt cancer cells to metastasize.

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image: Circadian Rhythms Influence Treatment Effects

Circadian Rhythms Influence Treatment Effects

By | April 1, 2017

Across many diseases, taking medication at specific times of day may make the therapy more effective.

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image: Targeting Tregs Halts Cancer’s Immune Helpers

Targeting Tregs Halts Cancer’s Immune Helpers

By | April 1, 2017

New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture.

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image: Opinion: Birds of a Feather?

Opinion: Birds of a Feather?

By | March 10, 2017

Taking into account the interaction of nuclear and mitochondrial genes in birds holds the promise of more objectively defining what constitutes a species.

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image: A Selection of CRISPR Proof-of-Principle Studies

A Selection of CRISPR Proof-of-Principle Studies

By | March 1, 2017

Advice on how to deploy the latest techniques in your own lab

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 Zebra finches reared by another species learn to sing their foster parents’ song with rhythms characteristic of their genetic background.

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image: Contributors

Contributors

By | March 1, 2017

Meet some of the people featured in the March 2017 issue of The Scientist.

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image: How Bad Singing Landed Me in an MRI Machine

How Bad Singing Landed Me in an MRI Machine

By | March 1, 2017

One author's journey through the science of his congenital amusia

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