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tag dna methylation histone methylation histone modification

Histone modification in heterochromatin
Jonathan Weitzman(jonathanweitzman@hotmail.com) | Feb 24, 2002 | 1 min read
The spatial organization of pericentric chromatin is established by histone acetylation and methylation, and involves an RNA component.
Targeted methylation
Jonathan Weitzman(jonathanweitzman@hotmail.com) | Dec 21, 2000 | 1 min read
Introducing methylated DNA at specific genomic loci affects local histone acetylation.
Histone codes
Jonathan Weitzman(jonathanweitzman@hotmail.com) | Mar 18, 2001 | 1 min read
The histone code hypothesis posits that distinct combinations of histone modifications can recruit chromatin-modifying enzymes and exert epigenetic control over heterochromatin assembly. In the March 15 ScienceXpress, Nakayama et al. describe a role for histone methylation in heterochromatin assembly in the fission yeast Schizosaccharomyces pombe. The Clr4 protein methylated lysine 9 of histone H3 (H3Lys9) preferentially within heterochromatin-associated regions. H3Lys9 methylation led to the r
Histone Methylation is Making its Mark
Brendan Maher | Jan 26, 2003 | 6 min read
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. M. Lachner et al., "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins," Nature, 410:116-20, 2001. (Cited in 202 papers) A.J. Bannister et al., "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain," Nature, 410:120-4, 2001. (Cited in 2
Profiling Human Histones
The Scientist Staff | Jul 1, 2007 | 1 min read
Some patterns of histone methylation are linked to human gene activation, and other patterns are linked to gene repression. By combining chromatin immunoprecipitation with new Solexa 1G sequencing technology, Artem Barski at the National Institutes of Health and colleagues from the University of California, Los Angeles, generated genome-wide maps for histone methylations and correlated methylation events with different levels of gene expression.1 The researchers saw differences in methy
Heritable Histones
Ruth Williams | Sep 18, 2014 | 3 min read
Scientists show how roundworm daughter cells remember the histone modification patterns of their parents.
Methylation mystery
Kelly Rae Chi | Oct 1, 2007 | 2 min read
David Allis from Rockefeller University and colleagues used a biochemical pull-down assay and found that the protein WDR5, a common part of histone methyltransferase complexes, associates specifically with dimethylated H3K4 nucleosomes.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
The Histone Code
Brendan Maher | Jan 26, 2003 | 2 min read
5-Prime | The Histone Code Courtesy of IMP/TKadletz What is the histone code? Different chemical marks, such as acetylation, methylation, or phosphorylation, are made to numerous residues on the N-terminal tails of histone proteins. Some posit that they act as readable and specific landing pads for proteins that control chromatin modeling and transcriptional regulation. The marks appear to be clustered in different regulatory groups signifying "on" and "off" portions of the genome, and som
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017 | 10+ min read
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.

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