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image: An Epi Phenomenon

An Epi Phenomenon

By | December 1, 2012

While exploring the genetics of a rare type of tumor, Stephen Baylin discovered an epigenetic modification that occurs in most every cancer—a finding he’s helping bring to the clinic.

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image: The Epigenetic Lnc

The Epigenetic Lnc

By | October 1, 2012

Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa

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image: Lamarck and the Missing Lnc

Lamarck and the Missing Lnc

By | October 1, 2012

Epigenetic changes accrued over an organism’s lifetime may leave a permanent heritable mark on the genome, through the help of long noncoding RNAs.

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image: Combing the Cancer Genome

Combing the Cancer Genome

By | March 1, 2012

A guided tour through the main online resources for analyzing cancer genomics data

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image: First, Do No Harm…

First, Do No Harm…

By | June 9, 2011

Is DNA damage an inevitable consequence of epigenetic reprogramming?

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image: Epigenetic Changes in Cancer

Epigenetic Changes in Cancer

By | March 1, 2011

The study of how covalent marks on DNA and histones are involved in the origin and spread of cancer cells is also leading to new therapeutic strategies.

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The Mark of Faith

By | March 1, 2011

Testing a central tenet of epigenetic regulation

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image: Epigenetics and Society

Epigenetics and Society

By | March 1, 2011

Did Erasmus Darwin foreshadow the tweaking of his grandson’s paradigm?

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Ready, Reset, Go

By | March 1, 2011

Rudolf Jaenisch enjoys climbing mountains, rafting rapids, and unraveling the secrets of pluripotency—knowledge that could someday lead to personalized regenerative medicine.

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image: Epigenetics—A Primer

Epigenetics—A Primer

By | March 1, 2011

There are many ways that epigenetic effects regulate the activation or repression of genes. Here are a few molecular tricks cells use to read off the right genetic program.

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