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From bench to emergency room bedside

By | February 21, 2006

How do you move from elegantly constructed mouse knockouts like the ones presented at the linkurl:Keystone Symposium on Molecular Mechanisms of Cardiac Disease and Regeneration;http://www.the-scientist.com/blog/display/23130/ here in Santa Fe, New Mexico, to pesky wild-type humans who often seem to court heart attacks? If you?re linkurl:Elizabeth Nabel,;http://www.genome.gov/17015041 director of the linkurl:National Heart, Lung, and Blood Institute,;http://www.nhlbi.nih.gov/new/press/05-01-26.ht

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The name game

By | February 21, 2006

It?s a no-brainer that people who share last names usually share genes as well. I, for one, am often asked if I?m related to the Indian cricket player Sourav Ganguly. (Sadly, no.) But now there?s a scientific linkurl:study;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16488872&query_hl=8&itool=pubmed_docsum to back up such questions. The research, which focuses on paternal lineages, verifies what we all would have guessed: that sharing a surname inc

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Using FACS in the brain

By | February 21, 2006

This week?s advance online publication of __Nature Neuroscience__ linkurl:details a neat new technique;http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn1654.html called FACS-array profiling, which should be of interest to anyone studying central nervous system development. X. William Yang and colleagues at the University of California, Los Angeles, used transgenic mice from the linkurl:GENSAT;http://www.gensat.org (gene expression nervous system atlas) project to compare gene expression

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Baffled by ESOF's newsletter

By | February 20, 2006

I think anyone who received last week's Euroscience Open Forum (ESOF) linkurl:newsletter;http://www.esof2006.org/blog_list.php4 would have been forgiven for wondering why the main article was entitled ?What is Islamism?? ESOF is a science meeting and its emailed newsletters are presumably designed to build interest levels prior to the event. Previous editions had covered fairly routine territory?lasers, neurons, galaxies, microbes, science journalists and the origin of the universe?which made t

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Epigenetics and the heart

By | February 20, 2006

Epigenetics and chromatin remodeling, it turns out, may play a role in heart disease. In one of two keynote addresses that opened the Keystone Symposia?s meeting on Molecular Mechanisms of Cardiac Disease and Regeneration here in Santa Fe, New Mexico, linkurl:Eric Olson;http://hamon.swmed.edu/faculty/olson2001.html showed why he?s received a number of awards from the American Heart Association, and why one of his earlier papers, linking calcineurin to cardiac hypertrophy, was a linkurl:Hot Paper

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More Korean research problems

By | February 16, 2006

In the latest of a long line of developments, Columbia University appears to have withdrawn its name from a linkurl:2001 study;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11584476&query_hl=7&itool=pubmed_docsum in the Journal of Reproductive Medicine co-authored by Korean researcher Kwang Yul Cha. During the study, prayer appeared to boost the success of in vitro fertilization (IVF), even though infertile couples weren?t aware of the intervention.

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Victories and Warnings for Evolution

By | February 15, 2006

So the Ohio School Board overturned a previous decision to add wording about ?critical analysis? of evolutionary theory. Though the wording sounds somewhat innocuous several evolution defenders have painted it as the next permutation of Intelligent Design?s grand plans to cram a creation story into science class. So, this is an important victory and only one of the first that can be nearly directly attributed to the outcome of the Dover case. Quotes from the __New York Times__ linkurl:article

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Royal Society seeking 'white knight'

By | February 14, 2006

An urgent plea has gone out from Britain's Royal Society, calling for a ?white knight? to buy some notes written by Robert Hooke in the late 1600s and make them available to researchers. Hooke worked with Robert Boyle, coined the term 'cell' and helped rebuild London, among other things. He was an early secretary of the Royal Society and the papers in question are annotated and draft minutes from early meetings. Given all of which, it seems a shame that the Royal Society isn't in a financial

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This time, the Times may be a little off

By | February 14, 2006

When I saw this month?s linkurl:cover story;http://www.the-scientist.com/2006/2/1/26/1/ earned a mention in Monday?s New York Times article called "Reporters find science journals harder to trust, but not easy to verify," my eyes lingered over both the headline of the story and the writer?s take on our article? namely, that the rocketing rate of submissions to top-tier journals was "weakening the screening process." On the one hand, I see her point. While journals appear to

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Epigenetics in Australia -- and New York

By | February 13, 2006

After 27 years, Australia's Lorne Conference on the Organization and Expression of the Genome witnessed a first on Sunday: a session dedicated to the joys of linkurl:epigenetics;http://www.the-scientist.com/blog/display/23011/ . The session kicked off with Carmen Sapienza from the Fels Institute for Cancer Research and Molecule Biology, Temple University School of Medicine, who showed using a combination of database analysis and lab work that imprinted chromosomal regions are historical hot-sp

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