clinical trials

As COVID-19 therapies get emergency-use green lights, the Biden administration must organize a therapeutic review board to help identify what’s working and what’s not.

Long before Moderna’s and Pfizer’s COVID-19 shots, scientists had been considering the use of genetically encoded vaccines in the fight against infectious diseases, cancer, and more.

The results mark the second experimental COVID-19 vaccine to show high efficacy, but the study is not complete and the data have not been peer reviewed.

Vaccine experts say the results surpass their expectations, but the study is not complete, and the data have not been peer reviewed.

Researchers propose that an infusion of memory T cells from people who have recovered from SARS-CoV-2 infections could treat severe disease.

A vaccine expert explains that such answers likely won’t come until a vaccine has already been approved and administered to millions of people.

Recent data show that the drug bamlanivimab, also known as LY-CoV555, does not appear to help those with severe cases of COVID-19, but trials continue for milder cases.

The company voluntarily paused its studies, including one in Phase 3, after an unexplained illness in a patient.

Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.

The University of Alabama at Birmingham neuroscientist aims to determine which cells are most important in prompting the disease’s initiation and progression.

Eli Lilly reports a 72 percent reduction in hospitalization risk among patients who received its monoclonal antibody compared to those who received a placebo.

A randomized controlled trial on the use of convalescent plasma therapy to treat coronavirus infections—the first in the world to be completed—yields disappointing results, but some doctors are not discouraged.

Almost 40 scientists have signed an open letter, citing odd patterns in the data and a lack of transparency after authors withheld the full data.

The hold will likely delay trial results, and scientists say the pause is proof that safety protocols in clinical trials are working as they should.

A meta-analysis of seven randomized controlled trials concludes that dexamethasone and other corticosteroids reduce 28-day mortality in seriously ill patients.

After six months, patients with fast-progressing amyotrophic lateral sclerosis who had received the experimental treatment had less loss of function than those who received a placebo.

UPenn’s Katharine Bar discusses ongoing clinical trials to explore the efficacy of treating patients with plasma from individuals who have recovered from an infection.

In clinical studies worldwide, researchers are testing the possibility that supplements of the vitamin could prevent or decrease the severity of SARS-CoV-2 infections.

Citizen advocates push the pharmaceutical company to examine a compound that has been used to treat certain coronavirus infections in cats.