The new technique reveals unprecedented details of microscopic life.
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Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa
Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes. They consist of hexameric nucleotide sequences (TTAGGG in humans) repeated hundreds to thousands of times. Telomeres protect the protein-coding sequences of DNA on
A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. In order to replicate the structure of an enzyme’s transition state, whic
Vitamin D has a variety of actions in the body. It binds to the vitamin D receptor (VDR), which then binds to the retinoid X receptor (RXR) and activates the expression of numerous genes. Through this mechanism, vitamin D promotes calcium absorption
In fewer than 15 years, nanomedicine has gone from fantasy to reality.
Isolating specific cell types from a mass of plant or animal tissue is laborious and tricky. To study epigenetic changes and genes that are expressed differently in different cell lineages—such as cancer cells versus normal cells, or the two types of
Using synchrotron rapid scanning X-ray fluorescence to map the distribution of trace metals in avian fossils over 120 million-year-old, researchers reconstruct the pigment patterns of their feathers—revealing some of the extinct birds' long-lost colo
The optogenetic toolset is composed of genetically encoded molecules that, when targeted to specific neurons in the brain, enable the electrical activity of those neurons to be driven or silenced by light. When these opsins are expressed in the lipid
Meet some of the finalists of this year's Best Places to Work in Academia survey. Read the full story. [gallery]
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