Although fully organized patient-run trials are still few and far between, patients are taking a more active role in clinical research.
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In 1929 and 1930, Johns Hopkins Medical School surgeon Warfield Firor carried out a series of experiments to determine how long blood could flow between animals with joined circulatory systems. Without using any anti-coagulants, Firor attempted to es
Gene therapies typically involve the introduction of genetic material into target cells to replace or supplement an existing, usually dysfunctional, gene. Techniques for delivering the corrective payload vary widely. Many gene therapies utilize modif
A rare peek inside the subterranean home of the naked mole-rat
Sangamo Biosciences is putting a different spin on gene therapy. Rather than replace or supplement a mutated gene with an accurate copy, Sangamo researchers are introducing a mutant copy of the gene for the HIV co-receptor CCR5 into the T cells of HI
Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes. They consist of hexameric nucleotide sequences (TTAGGG in humans) repeated hundreds to thousands of times. Telomeres protect the protein-coding sequences of DNA on
A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. In order to replicate the structure of an enzyme’s transition state, whic
Chemical ecologist Max Suckling at the Institute for Plant and Food Research Ltd., and summer student Rachael Sagar use Pavlovian conditioning to train bees to stick out their tongues, or proboscises, at the scent of odors produced by tuberculosis-ca
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