Itzhaki | Apr 14, 2002 | 2 min read
I and my group heartily agree with Edward L. McNeil1 about the need to search for infectious agents in idiopathic diseases, although there is often the problem of cause and effect: Detection of an infectious agent in the diseased tissue does not necessarily mean that it is involved in the pathogenesis of the disease. However, in Alzheimer disease (AD) an infectious agent has indeed been sought—and found, and implicated directly as a cause. Using polymerase chain reaction (and taking extrem