techniques, genetics, genetics & genomics

Researchers find that SARS-CoV-2 variants can evade primer-probe sets and recommend that diagnostic assays include multiple targets for reliability.

The embryos completed one-third of their total gestation outside of a uterus.

Genes that are exceptionally long or short are overrepresented in some published reports, which can lead to misinterpreted results.

In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.

All six calves inherited the gene for preventing horn growth, but four also got a piece of the plasmid used to introduce the sequence to their dad—complicating regulatory approval.

Chips used by some direct-to-consumer genetic testing firms display a false positive rate of upwards of 85 percent when screening for rare variants, a new study finds.  

Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.

Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.

A number of rare diseases show unique epigenetic patterns across the genome, a feature researchers have now exploited to build a diagnostic tool.

The group had argued that a patent given to the Broad Institute overlapped with this one.

Since He Jiankui presented his results at last week’s gene editing summit, researchers have raised concerns about his protocol, calling the procedure “amateurish” and “unconscionable.”

Researchers from 17 labs report low efficacy rates for the popular technique.

Using bioinformatics, two teams of scientists identified inhibitory proteins for Cas9’s relative.

The European Union says no thanks.

Brief electroporation appears to make T cells more receptive to new genetic material, which could speed the development of immunotherapies.

It’s the first demonstration of the technology in mammals.

Scientists at the Allen Institute for Cell Science have developed an open-source stem cell line with fluorescent tags for cardiac cells.

The new technique uses an enzyme found in vertebrate immune systems to attach nucleotides to a growing strand.