techniques, genetics

A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.

A study shows “sonogenetics” could be a useful new tool in neuroscience and other fields.

A new method helps researchers uncover the rules of ribosome recruitment in yeast.

The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.

Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.

Researchers find that SARS-CoV-2 variants can evade primer-probe sets and recommend that diagnostic assays include multiple targets for reliability.

The embryos completed one-third of their total gestation outside of a uterus.

An enzyme pulled from toxic bacteria can enter the organelle and perform single-nucleotide DNA swaps.

Genes that are exceptionally long or short are overrepresented in some published reports, which can lead to misinterpreted results.

In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.

All six calves inherited the gene for preventing horn growth, but four also got a piece of the plasmid used to introduce the sequence to their dad—complicating regulatory approval.

Genetic engineers have co-opted base editing machinery to enable information storage and processing in the DNA of bacterial and mammalian cells.

Chips used by some direct-to-consumer genetic testing firms display a false positive rate of upwards of 85 percent when screening for rare variants, a new study finds.  

Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.