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image: Designing Transition-State Inhibitors

Designing Transition-State Inhibitors

By | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. 

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image: Suspected Effects of Vitamin D

Suspected Effects of Vitamin D

By | March 1, 2012

Vitamin D has a variety of actions in the body. It binds to the vitamin D receptor (VDR), which then binds to the retinoid X receptor (RXR) and activates the expression of numerous genes. 

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image: Swallowing the Surgeon

Swallowing the Surgeon

By | October 1, 2011

In fewer than 15 years, nanomedicine has gone from fantasy to reality.

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image: The Right Sort

The Right Sort

By | August 1, 2011

Isolating specific cell types from a mass of plant or animal tissue is laborious and tricky. 

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image: Repainting Ancient Birds

Repainting Ancient Birds

By | July 1, 2011

Using synchrotron rapid scanning X-ray fluorescence to map the distribution of trace metals in avian fossils over 120 million-year-old, researchers reconstruct the pigment patterns of their feathers—revealing some of the extinct birds' long-lost colors.

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image: OPSINS: Tools of the trade

OPSINS: Tools of the trade

By | July 1, 2011

The optogenetic toolset is composed of genetically encoded molecules that, when targeted to specific neurons in the brain, enable the electrical activity of those neurons to be driven or silenced by light. 

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image: Best in Academia, 2011

Best in Academia, 2011

By | July 1, 2011

Meet some of the finalists of this year's Best Places to Work in Academia survey. 

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image: Meet the Crystal Smasher

Meet the Crystal Smasher

By | July 1, 2011

Take a tour of the Linac Coherent Light Source (LCLS), whose ultra-powerful X-ray beam is being used to solve the structures of proteins that are notoriously hard to crystallize.

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image: Optogenetics: A Light Switch for Neurons

Optogenetics: A Light Switch for Neurons

By | July 1, 2011

This animation illustrates optogenetics—a radical new technology for controlling brain activity with light. 

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image: Smashing Crystals

Smashing Crystals

July 1, 2011

A powerful new X-ray–generating laser is imaging smaller crystals than ever before.

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