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2022 Top 10 Innovations
2022 Top 10 Innovations
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
2022 Top 10 Innovations
2022 Top 10 Innovations

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

imaging, techniques

Conceptual image of blue neurons with glowing segments over blue background.
CRACK Method Reveals Novel Neuron Type in Mouse Brain
Dan Robitzski | Apr 18, 2022 | 3 min read
A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.
Illustration showing how calcium imaging and HCR-FISH combined is a technique called comprehensive readout of activity and cell type markers (CRACK)
Infographic: Simultaneously Studying Neuron Structure and Function
Dan Robitzski | Apr 18, 2022 | 1 min read
A new methodology combines existing techniques to reveal the specific function and location of multiple types of neurons at once.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
A Bright New Tool to Record Cellular Interactions
Lisa Winter | Apr 1, 2021 | 3 min read
The G-baToN prototype transfers GFP between cells, illuminating cell-cell contacts.
The Hidden World of Millipede Sex
Yao-Hua Law | Jun 1, 2020 | 4 min read
Researchers use advanced imaging techniques to see what happens when a male and a female mate.
Blood Test Detects Cancer Early, But Has Some Holdups
Ashley Yeager | Apr 29, 2020 | 2 min read
The liquid biopsy, which detects cell-free tumor DNA, spotted undiagnosed cancers in some women, but had a greater number of false positives and false negatives.
Microscopy and Imaging Leader Shinya Inoué Dies
Jef Akst | Oct 7, 2019 | 1 min read
The long-time Marine Biological Laboratory scientist was known for using his own hand-built microscopes to image the dynamics of live cells.
New Tissue Clearing Methods Offer a Window into the Brain
Andy Tay | Oct 1, 2019 | 7 min read
Researchers are developing a variety of approaches for clearing neural tissue to get a better view of the brain’s circuitry.
traced mouse neurons
Image of the Day: Brain Map
Nicoletta Lanese | Sep 6, 2019 | 1 min read
Scientists traced 1,000 neurons through the mouse brain, uncovering new details about how the organ is wired.
translation gene genetics ribosome enhancers knowable magazine
What Does It Look Like to “Turn On” a Gene?
Alla Katsnelson, Casey Rentz, and Knowable Magazine | May 3, 2019 | 8 min read
Only recently have scientists directly witnessed this most pivotal of events in biology, thanks to new technology that allows them to observe the process in living cells. It’s teaching them a lot.
ChroMS chromatic multiphoton serial microscopy brain imaging mouse
Image of the Day: Multicolor Brain
Chia-Yi Hou | Apr 22, 2019 | 1 min read
A newly developed imaging technology visualizes entire mouse brains in two and three dimensions using multicolor fluorescence microscopy.
AI Networks Generate Super-Resolution from Basic Microscopy
Jef Akst | Dec 17, 2018 | 3 min read
A new study uses deep learning to improve the resolution of biological images, but elicits skepticism about its ability to enhance snapshots of sample types that it has never seen before.
Image of the Day: Bright Idea
Shawna Williams | Nov 5, 2018 | 1 min read
Researchers flipped light-sensitive proteins upside down for a new twist on optogenetics.
Image of the Day: First Contact
Catherine Offord | Oct 11, 2018 | 1 min read
Cryo-electron tomography reveals how Salmonella sets up physical interactions with host cells.
Image of the Day: The Birth of a Nervous System
Jef Akst | Oct 2, 2018 | 1 min read
The winner of the 2018 Nikon Small World in Motion video competition shows the development of sensory neurons in a zebrafish embryo.
Drones Are Changing the Face of Ecology
Catherine Offord | Aug 1, 2018 | 6 min read
Unmanned aerial vehicles allow researchers to collect huge volumes of biological data cheaply, easily, and at higher resolution than ever before.
Image of the Day: Rainbotubules
The Scientist and The Scientist Staff | Apr 26, 2018 | 1 min read
By combining two microscopy techniques, researchers produce images of structures less than 10 nanometers wide.
Optical Cell Sorting
Rachel Berkowitz | Dec 1, 2017 | 7 min read
Researchers are using light and new image processing tools for label-free cell characterization.
Caught in the Act
Devika G. Bansal | Nov 1, 2017 | 6 min read
Molecular probes for imaging in live animals
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