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rna-seq rna sequencing bias dataset transcript
Technical Bias Widespread in RNA-Seq Datasets
Diana Kwon | Nov 21, 2019 | 3 min read
Genes that are exceptionally long or short are overrepresented in some published reports, which can lead to misinterpreted results.
prime editing crispr cas9 genome editing techniques
New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts
Emma Yasinski | Oct 21, 2019 | 4 min read
In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.
buri recombinetics hornell cow hereford bull polled genetically engineered talens gmo cattle livestock
Genome-Edited Hornless Cows’ Offspring Are Healthy: Study
Kerry Grens | Oct 9, 2019 | 2 min read
All six calves inherited the gene for preventing horn growth, but four also got a piece of the plasmid used to introduce the sequence to their dad—complicating regulatory approval.
Accuracy of Genotyping Chips Called into Question
Grace Browne | Jul 24, 2019 | 4 min read
Chips used by some direct-to-consumer genetic testing firms display a false positive rate of upwards of 85 percent when screening for rare variants, a new study finds.  
crispr dna detection
Infographic: DNA Detection with a Chip
Ruth Williams | Jul 15, 2019 | 1 min read
Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.
Advances in the functional characterization of newly discovered microproteins hint at their diverse roles  in health and disease
The Dark Matter of the Human Proteome
Annie Rathore | Apr 1, 2019 | 10 min read
Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.
episignature epigenetics rare disease
Researchers Analyze Epigenetic Signatures to Diagnose Rare Diseases
Katarina Zimmer | Mar 28, 2019 | 5 min read
A number of rare diseases show unique epigenetic patterns across the genome, a feature researchers have now exploited to build a diagnostic tool.
UC Berkeley Team to Be Awarded CRISPR Patent
Kerry Grens | Feb 11, 2019 | 2 min read
The group had argued that a patent given to the Broad Institute overlapped with this one.
CRISPR Scientists Slam Methods Used on Gene-Edited Babies
Katarina Zimmer | Dec 4, 2018 | 6 min read
Since He Jiankui presented his results at last week’s gene editing summit, researchers have raised concerns about his protocol, calling the procedure “amateurish” and “unconscionable.”
Study Challenges CRISPR Method for Making Conditional Knockout Mice
Sukanya Charuchandra | Sep 28, 2018 | 3 min read
Researchers from 17 labs report low efficacy rates for the popular technique.
Anti-CRISPR Proteins Found that Block Cas12a Nuclease
Ashley Yeager | Sep 6, 2018 | 1 min read
Using bioinformatics, two teams of scientists identified inhibitory proteins for Cas9’s relative.
USDA Unveils New Gene-Stacking Tool to Prevent Plant Diseases
Anne N. Connor | Aug 14, 2018 | 4 min read
The European Union says no thanks.
Electric Shock Allows for CRISPR Gene Editing Without a Viral Vector
Ashley Yeager | Jul 12, 2018 | 2 min read
Brief electroporation appears to make T cells more receptive to new genetic material, which could speed the development of immunotherapies.
CRISPR Gene Drive Used to Alter Mouse Coat Color
Shawna Williams | Jul 9, 2018 | 2 min read
It’s the first demonstration of the technology in mammals.
Image of the Day: Beating Heart
Sukanya Charuchandra | Jul 2, 2018 | 1 min read
Scientists at the Allen Institute for Cell Science have developed an open-source stem cell line with fluorescent tags for cardiac cells.
Novel Method Could Accelerate DNA Synthesis
Sukanya Charuchandra | Jun 19, 2018 | 2 min read
The new technique uses an enzyme found in vertebrate immune systems to attach nucleotides to a growing strand.  
Researchers Produce Alpaca Antibodies Using Yeast
Catherine Offord | Feb 13, 2018 | 2 min read
With multiple applications in biomedicine, the antibodies can now be made quickly, cheaply, and without the need for an alpaca or one of its relatives.
CRISPR Helps Mice Hear
Abby Olena, PhD | Dec 20, 2017 | 3 min read
Researchers reduce the severity of hereditary deafness in mice with the delivery of CRISPR-Cas9 protein-RNA complexes that inactivate a mutant gene in their inner ears. 
Nonviral CRISPR Delivery a Success
Abby Olena, PhD | Oct 2, 2017 | 3 min read
Researchers use gold nanoparticles to deliver CRISPR-Cas9 and correct a point mutation in a mouse model of Duchenne muscular dystrophy. 
Was a Drop in CRISPR Firms’ Stock Warranted?
Claire Asher | Jun 7, 2017 | 4 min read
A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.
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