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Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds

Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.

Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.

cancer, genetics & genomics, disease & medicine

Paul Marks, Past President of MSKCC, Dies
Catherine Offord | May 8, 2020 | 3 min read
A cancer researcher with a talent for leadership, Marks turned the Memorial Sloan Kettering Cancer Center into one of the world’s foremost oncology research institutions.
Infographic: How Some X-Chromosome Genes Escape Inactivation
Amber Dance | Mar 1, 2020 | 2 min read
About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time.
Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Amber Dance | Mar 1, 2020 | 10+ min read
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
CRISPR-Edited Cells for Cancer Therapy Safe in Humans: Trial
Ashley Yeager | Feb 6, 2020 | 3 min read
In the first clinical study of its kind in the US, researchers used CRISPR to modify CAR T cells to make them more potent against cancer, but the clinical benefits are unknown.
Immunology Leader Vincenzo Cerundolo Dies
Ashley Yeager | Jan 16, 2020 | 2 min read
The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.
Cigall Kadoch Unravels Chromatin’s Role in Cancer
Chia-Yi Hou | Sep 1, 2019 | 3 min read
The Dana-Farber Cancer Institute researcher is developing cancer therapeutics based on how the physical structure of DNA contributes to the disease.
Even Healthy Tissues Carry Clusters of Cells with Mutations: Study
Ashley Yeager | Jun 7, 2019 | 2 min read
Most of the genetic alterations are harmless, but some may contribute to cancer.
nancy davidson fred hutch epigenetics breast cancer
Q&A: Epigenetic Therapies for Breast Cancer
Katarina Zimmer | Apr 4, 2019 | 4 min read
Breast cancer researcher and oncologist Nancy Davidson discusses what we’ve learned from the first wave of epigenetic trials for breast cancer, and what challenges lie ahead before such therapies reach the clinic.
april 2019 crossword
Ten-Minute Sabbatical
The Scientist | Apr 1, 2019 | 2 min read
Take a break from the bench to puzzle and peruse.
cancer more common in men
Why Is Cancer More Common in Men Than in Women?
Jef Akst | Apr 1, 2019 | 4 min read
The molecular processes that lead males to be more susceptible to the disease are only beginning to come to light.
More Cancer Mutations, Better Immunotherapy Outcomes
Catherine Offord | Jan 15, 2019 | 2 min read
Immune checkpoint inhibitors are generally most effective against tumors with more genetic mutations, according to a new study, although the relationship isn’t true for all cancers.
Eli Lilly Will Buy Loxo Oncology for $8 Billion
Ashley Yeager | Jan 8, 2019 | 2 min read
Loxo focuses on cancer treatments based on tumor genetics, which will contribute to Lilly’s push in the cancer drug space.
Genome, Exome, RNA Sequencing Applied to Pediatric Cancer Cases
Ashley Yeager | Oct 18, 2018 | 2 min read
Combining data from the genetic testing techniques can guide patient care, scientists say.
Thousands of BRCA1 Genetic Variants Functionally Characterized
Sukanya Charuchandra | Sep 13, 2018 | 2 min read
The researchers catalogued 3,893 variants of the gene implicated in cancer using CRISPR.
CRISPR Gene Editing Deletes, Shuffles More Genes than Intended
Ashley Yeager | Jul 16, 2018 | 2 min read
The DNA-cutting enzyme used in the technique is not as precisely targeted as scientists had thought, and investors take notice.
Artificial Intelligence to Boost Liquid Biopsies
Claire Asher | Jun 26, 2018 | 4 min read
Machine-learning algorithms tuned to detecting cancer DNA in the blood could pave the way for personalized cancer care.
Image of the Day: New Kids on the Block
Sukanya Charuchandra | Jun 7, 2018 | 1 min read
Researchers discover that a layer of human breast tissue is not one but two distinct cell types.  
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