disease & medicine, genetics & genomics

Breast cancer researcher and oncologist Nancy Davidson discusses what we’ve learned from the first wave of epigenetic trials for breast cancer, and what challenges lie ahead before such therapies reach the clinic.

Take a break from the bench to puzzle and peruse.

The molecular processes that lead males to be more susceptible to the disease are only beginning to come to light.

Researchers can now track the expansion of a resistance mechanism that allows the malaria vector Anopholes funestus to detoxify a key insecticide used on bed nets.

Certain populations have been historically underrepresented in genome sequencing studies, but the NIH, private clinics, and 23andMe and other companies are trying to fix that.

The advisors’ recommendations follow news of ethically dubious gene-editing work carried out by He Jiankui late last year.

The Duke University professor studies the parasite to find a way to thwart infection before it takes hold.

The large-scale experiments aim to test how the technology would fare in the wild, if deployed to knock down populations of the pests.

The research is among the first to find the connection in humans.

Researchers find that it’s not just high-risk genes, but how children’s bodies respond to their own intestinal microbiota that relates to future diagnoses of type 1 diabetes.

Immune checkpoint inhibitors are generally most effective against tumors with more genetic mutations, according to a new study, although the relationship isn’t true for all cancers.

Loxo focuses on cancer treatments based on tumor genetics, which will contribute to Lilly’s push in the cancer drug space.

Deep-learning algorithms could help doctors narrow in on the causes of certain medical conditions, say researchers.

A trial called BabySeq, in which researchers performed genomic sequencing on 159 newborns, identified children susceptible to diseases that regular screening doesn’t look for.

Large-scale genomic studies of anorexia and bulimia are turning up clues about the conditions’ development and persistence.

The PsychENCODE project delves into the DNA, RNA, and protein changes related to brain development and neuropsychiatric disorders, but researchers caution it’s just a first step toward treatment.

He Jiankui says he has successfully used CRISPR-Cas9 to tweak the genes of twins born earlier this month. Some independent experts are dubious.

The new data could help identify treatments for diseases ranging from river blindness to schistosomiasis.

Combining data from the genetic testing techniques can guide patient care, scientists say.