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tag genetics genomics cancer drug development
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD
| Mar 7, 2024
| 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening.
Silencing Epigenetic Complexes Re-sensitizes Drug-Resistant Cancer Cells
Rachael Moeller Gorman
| Sep 25, 2023
| 4 min read
Researchers studying lung cancer cell lines found that chromatin remodeling underlies one type of osimertinib resistance.
Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD
| Jan 18, 2024
| 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Ancient Viral DNA Plays a Role in Human Disease and Development
Aidan Burn,
The Conversation
| Oct 19, 2022
| 4 min read
Viral remnants make up 8 percent of the human genome, and a new study finds that these sequences are still active in healthy people.
Cancers Protect Themselves Against Their Own Mutations
Ida Emilie Steinmark, PhD
| Aug 1, 2023
| 2 min read
Tumors overexpress certain genes to survive a growing pile of harmful mutations, a trait that scientists could exploit to target with drugs.
Turning on the Bat Signal
Hannah Thomasy, PhD
| Mar 15, 2024
| 10+ min read
Scientists around the world investigate how bat immune systems cope with viral attacks and how this information could be used to keep humans safe.
Next-generation CAR and TCR Cancer Therapies
Danielle Gerhard, PhD
| Mar 15, 2024
| 10+ min read
From smart receptors to novel biologics, scientists plan to overcome the challenges of treating solid tumors.
Precision Medicine: A New Era in Cancer Therapy
Rebecca Roberts, PhD
| Dec 15, 2023
| 6 min read
Precision medicine helps clinicians tailor individual treatments, addressing genetic mutations, tumor microenvironment variations, and therapeutic resistance.
The Cre-
loxP
System: A Powerful Tool in the Genetic Toolbox
Laura Tran, PhD
| Dec 4, 2023
| 9 min read
Standing at the cornerstone of genetic research, Cre-
loxP
recombination serves as molecular scissors for precisely manipulating the genome.
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Jef Akst
| Apr 22, 2022
| 2 min read
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
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