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Fluorescence microscopy image of cells expressing fluorescent biosensors. Green and magenta fluorescence is observed outside of the cell nuclei.
Choosing Fluorescent Reagents for Every Live Cell Application
The Scientist and MilliporeSigma | Nov 30, 2022 | 4 min read
Scientists gain unique insights into active biological processes with specific fluorescent probes, dyes, and biosensors.
Keeping Tabs on Cultured Cells
Lissa Harris(lharris@the-scientist.com) | Mar 13, 2005 | 6 min read
THE CULTURE WITHIN:Photo courtesy of Drs. C.C. Uphoff and H.G. Drexler, DSMZ-German Collection of Microorganism and Cell Cultures, Braunschweig, GermanyHeLa cell line infected with Mycoplasma hyorhinis. Scanning electron micrograph of critical point-dried cell culture grown on cover slips. Note the loop- and rod-like mycoplasmas attached to the host cell membrane. Smaller web-like structures on the cell surface represent microvilli of the cell. Original magnification 3,000×.Mycoplasmas have
Special report
a hand in a blue glove holds a clear plastic multiwell plate in a laboratory with foil-wrapped plates on a metal shelf in the background
Labs Worldwide Still Struggling Amid Broken Supply Chains
Katarina Zimmer | May 21, 2021 | 8 min read
Countries outside the US and Europe that are already used to long wait times for laboratory supplies are facing greater research disruptions than ever during the pandemic.
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Assay for Sickle Cell Anemia Is Repurposed to Diagnose COVID-19
G.B.S.N.P. Varma | Nov 18, 2020 | 5 min read
A CRISPR-based, paper-strip test developed by Indian researchers performs as well as real-time PCR in identifying the presence of SARS-CoV-2 and returns results within an hour.
RNA Detection Tool Debate Flares Up at ACS Meeting  
Katarina Zimmer | Sep 5, 2018 | 5 min read
Researchers have flagged several issues with so-called SmartFlares over the years, and it’s still unclear why they don’t appear to work under certain circumstances.
New Products
The Scientist Staff | Feb 5, 1995 | 3 min read
The Ni-NTA spin columns provide purification of 6xHis-tagged proteins from small-scale expression cultures. Available in two formats--separately without reagents or as a complete kit--they can be used in experimental situations requiring small-scale expression, functional screening, and rapid purification of engineered and recombinant proteins. Each can purify up to 100 fg of 6xHis tagged protein under native or denaturing conditions. According to the manufacturer, this procedure allows 12 mini
Sharing Made Easy
Megan Scudellari | Sep 1, 2012 | 7 min read
Biological resource centers are bigger and better than ever before, storing and distributing shared reagents, plasmids, and more.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Out, Damned Mycoplasma!
Kelly Rae Chi | Dec 1, 2013 | 8 min read
Pointers for keeping your cell cultures free of mycoplasma contamination
a stock room with metal shelves lining each side
Supply Shortages Hit Life Science Labs Hard
Shawna Williams | Apr 21, 2021 | 6 min read
The pandemic continues to make it difficult for researchers to get reagents and other materials in high demand for COVID-19 research and testing, threatening experiments’ progress and scientists’ careers.

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