Michael Brush | Jul 20, 1997 | 10+ min read
When the next time around is always better. Date: July 21, 1997 Comparison Chart DNA sequencing methods have come a long way in 20 years. From the chemical method of Maxam and Gilbert and the dideoxy method of Sanger, DNA sequencing techniques evolved into the "labeling/termination" method that used a modified T7 DNA polymerase such as Sequenase. Propelled by the power and potential of DNA amplification using thermal cycling strategies, earlier DNA sequencing methodologies have increasingly b