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Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive

In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.

In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.

immunology, epigenetics

The Epigenetic Landscape During T Cell Exhaustion
The Epigenetic Landscape During T Cell Exhaustion
The Scientist and 10x Genomics | Jul 6, 2022 | 1 min read
In this webinar, E. John Wherry and Debattama Sen will discuss how epigenetic scarring of exhausted T cells influences chronic infections.
white mouse with pups
Doubts Raised Over Whether Mice Can Truly Inherit Immunity
David Adam | Jan 26, 2022 | 3 min read
An independent lab fails to replicate results suggesting mammals exposed to pathogens could pass on immunological protections through epigenetic mechanisms.
white adult mouse with 4 pups on white background
Mice that Survive Infection Pass on Stronger Immunity
David Adam | Oct 18, 2021 | 3 min read
Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.
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Capturing Heterogeneity: How Single Cell Analysis Reshapes Health and Disease Research
The Scientist | Sep 30, 2021 | 1 min read
Timothy O’Sullivan and Jacob Blum will discuss how they use single cell data to understand complex biological systems.
More than 40 New Papers on Epigenetics Published
Jef Akst | Nov 21, 2016 | 2 min read
The International Human Epigenome Consortium presents a series of studies on how epigenetics influences immunity, cell lineage determination, and differentiation.
Yun “Nancy” Huang: Eager for Epigenetics
Amanda B. Keener | Aug 1, 2015 | 3 min read
Assistant Professor, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston. Age: 35
Epigenetics of Trained Innate Immunity
Ruth Williams | Sep 25, 2014 | 3 min read
Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages.
Compact Model T
Hannah Waters | May 25, 2011 | 2 min read
Editor's choice in immunology
Epigenetics—A Primer
Stefan Kubicek | Mar 1, 2011 | 1 min read
There are many ways that epigenetic effects regulate the activation or repression of genes. Here are a few molecular tricks cells use to read off the right genetic program.
Epigenetics—A Primer
Stefan Kubicek | Mar 1, 2011 | 1 min read
Epigenetic events regulate the activities of genes without changing the DNA sequence. Different genes are expressed depending on the methyl-marks attached to DNA itself and by changes in the structure and/or composition of chromatin. 
Top 7 From F1000
N/A | Feb 28, 2011 | 3 min read
A snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000
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