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A small, brown mouse runs on a narrow, miniature treadmill
How Exercise Helps Mice Fight Pancreatic Cancer
Dan Robitzski | Jun 15, 2022 | 5 min read
A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022 | 3 min read
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
Artist's rendition of a yellow CAR T cell near a red cancer cell surrounded by red blood cells.
Ten Years On, CAR T Cell Recipient Is Still Cancer-Free
Jef Akst | Feb 3, 2022 | 2 min read
First, the genetically engineered cells became CD8+ killer T cells that wiped out his leukemia. Then they transformed into a stable population of CD4+ helper T cells that continue to circulate in his body.
Undone Proteins Take Out Bladder Cancer
Roni Dengler, PhD | Jul 20, 2021 | 3 min read
An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.
José Baselga, cancer, research, oncology, AstraZeneca, breast cancer, drugs, therapeutics, obituary, dies
José Baselga, Renowned Oncologist, Dies at 61
Asher Jones | Mar 22, 2021 | 2 min read
The cancer researcher and executive vice president of AstraZeneca’s oncology research and development is well known for his role in the development of pivotal breast cancer therapies.
Who Benefits from Herceptin and Other Anti-HER2 Cancer Therapies?
Robert Fortner | Apr 12, 2020 | 7 min read
Calls to include a new breast cancer subtype in future clinical trials reveal fundamental disagreements about HER2’s role in the disease.
CAR T Cell Adds Scorpion Venom to Tackle Tumor Heterogeneity
Amy Schleunes | Mar 24, 2020 | 5 min read
A newly engineered CAR T cell that incorporates a peptide isolated from the venom of the deathstalker scorpion has broad brain tumor–binding capabilities that will be investigated in an upcoming clinical trial.
smart pills
Smart Pills Help Monitor Cancer Patients’ Therapy
Chia-Yi Hou | Jul 15, 2019 | 5 min read
Sensors encapsulated with oral chemotherapy drugs help patients and physicians keep track of treatments.
personalized vaccines
Infographic: Neoantigen Prediction for Personalized Vaccine Design
Jasreet Hundal and Elaine R. Mardis | Jul 15, 2019 | 3 min read
See how a computational pipeline uses next-generation sequencing data to identify genetic alterations that produce cancer-specific antigens.
natural killer cells nk cell therapy product immunotherapy clinical trial
Clinical Trial Underway for a Natural Killer Cell Therapy
Chia-Yi Hou | May 7, 2019 | 3 min read
The cells, derived from induced pluripotent stem cells, are in testing as an immunotherapy for cancer patients with solid tumors.
april 2019 crossword
Ten-Minute Sabbatical
The Scientist | Apr 1, 2019 | 2 min read
Take a break from the bench to puzzle and peruse.
Opinion: Learning from Immunotherapy’s Recent Failures
Luis Felipe Campesato | Aug 1, 2018 | 6 min read
The promise of immunotherapy is real. We now need to figure out how to maximize the number of patients the approach benefits.
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
Vicki Brower | Apr 1, 2018 | 9 min read
With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.
CRISPR Trial for Cancer Patients Proposed
Katarina Zimmer | Jan 18, 2018 | 1 min read
US researchers could become the first outside China to use the gene-editing technique in the clinic. 
New CAR T-Cell Therapy Shows Promise in Trial for Leukemia
Katarina Zimmer | Nov 21, 2017 | 2 min read
The immunotherapy, which targets CD22 on cancer cells rather than CD19, might prove useful in patients for whom previous T-cell treatments were unsuccessful. 
More than 18,000 Genomic Records from Cancer Patients Available
Kerry Grens | Jun 1, 2017 | 2 min read
The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 
Rethinking a Cancer Drug Target
Catherine Offord | Mar 26, 2017 | 4 min read
The results of a CRISPR-Cas9 study suggest that MELK—a protein thought to play a critical role in cancer—is not necessary for cancer cell survival.
CRISPR Therapy to Enter Trials
Jef Akst | Jul 25, 2016 | 2 min read
Researchers in China will use the CRISPR-Cas9 system to edit T cells extracted from patients with cancer before those cells are returned to the body to target malignant ones.
Cancer Immunotherapy Trial Suspended After Deaths
Kerry Grens | Jul 8, 2016 | 3 min read
Juno Therapeutics asks the US Food and Drug Administration for permission to restart the CAR-T experiments without chemotherapy.
Two NIH Labs Cease Reagent Production
Kerry Grens | Apr 20, 2016 | 1 min read
Contamination concerns at cell therapy and radioactive tracer facilities spur production shutdowns.
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