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tag neuroscience dna methylation mutations

early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
DNA Methylation Linked to Memory Loss
Sabrina Richards | Jul 2, 2012 | 3 min read
Scientists find that declining DNA methylation in mouse neurons may cause age-related memory deficits.
a trio of infant mice, two brown mice on the ends and one white mouse in the middle
Mice Pass Epigenetic Tweaks to Pups
Katherine Irving | Feb 17, 2023 | 5 min read
An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.
Epigenetic Marks May Cause Brain Tumor Formation
Jennifer Zieba, PhD | Sep 19, 2023 | 3 min read
Scientists established an epigenetic mouse model for glioma, providing insight into how epigenetics can initiate cancer.
Microscopy image showing patches of magenta and green
Three Autism-Linked Genes Converge on Tweaks to Cells’ Timing
Angie Voyles Askham, Spectrum | Feb 3, 2022 | 3 min read
The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.
Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Genetic Brain Disorder Explained
Rina Shaikh-Lesko | Apr 25, 2014 | 2 min read
Researchers uncover a mutation responsible for a rare neurological condition.
Research Notes
Nadia Halim | Feb 20, 2000 | 6 min read
Methylation as a Cancer Switch Courtesy of Richard Roberts, New England BiolabsReaction model: Methyltransferase (white) is methylating cyclic carbon 5 of a cytosine nucleotide. The tenuous link between cancer and epigenetic changes, changes in gene expression without DNA mutations, has been strengthened by Joe Costello, assistant professor at the University of California, San Francisco, and colleagues (J.F. Costello et al., "Aberrant CpG-island methylation has non-random and tumour-type-specifi
Week in Review: July 7–11
Tracy Vence | Jul 11, 2014 | 3 min read
Assessing mtDNA mutations among healthy people; heritability of intelligence; epigenetic inheritance of maternal malnutrition markers; consumers buy into DNA ancestry

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