In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

Scientists established an epigenetic mouse model for glioma, providing insight into how epigenetics can initiate cancer.

Is DNA damage an inevitable consequence of epigenetic reprogramming?

Scientists find that declining DNA methylation in mouse neurons may cause age-related memory deficits.

Unlike animals, plants stably pass on their DNA methylomes from one generation to the next. The resulting gene silencing likely hides an abundance of phenotypic variation.

New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.

Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.

The concept of epigenetic inheritance has long been controversial. Some researchers hope that new data on cross-generational effects of environmental exposures will help settle the debate.

Epigenetic structures appear to reduce the rate of changes in genes essential for survival and reproduction, a study finds, challenging the notion that mutations are evenly distributed throughout the genome prior to selection.