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Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Pulling It All Together
Kate Yandell | Apr 1, 2016 | 9 min read
Systems-biology approaches offer new strategies for finding hard-to-identify drug targets for cancer.
Tagged for Cleansing
Michele Pagano | Jun 1, 2009 | 10+ min read
Tagged for Cleansing Not just the cell's trash and recycling center, the ubiquitin system controls complex cellular pathways with elegant simplicity and precision. By Michele Pagano have always gravitated toward order. I may even take it a bit too far according to friends who liken my office to a museum. However, I like to think it not a compulsion, but a Feng Shui approach to life. With this need for order, I may have been better suited to
Epigenetics: Genome, Meet Your Environment
Leslie Pray | Jul 4, 2004 | 10+ min read
©Mehau Kulyk/Photo Researchers, IncToward the end of World War II, a German-imposed food embargo in western Holland – a densely populated area already suffering from scarce food supplies, ruined agricultural lands, and the onset of an unusually harsh winter – led to the death by starvation of some 30,000 people. Detailed birth records collected during that so-called Dutch Hunger Winter have provided scientists with useful data for analyzing the long-term health effects of prenat
How We Age
The Scientist | Mar 1, 2015 | 10+ min read
From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.
Can Destroying Senescent Cells Treat Age-Related Disease?
Katarina Zimmer | Mar 1, 2020 | 10+ min read
A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.
How Orphan Drugs Became a Highly Profitable Industry
Diana Kwon | May 1, 2018 | 10+ min read
Government incentives, advances in technology, and an army of patient advocates have spun a successful market—but abuses of the system and exorbitant prices could cause a backlash.
Applications Of Image Analysis Systems Expand Beyond The Research Lab
Ricki Lewis | Oct 27, 1996 | 10+ min read
TIME EFFICIENT: The AMBIS radioisotopic imager from Scanalytics/CSPI. Already an invaluable tool in some basic research, image analysis is edging into the classroom and the clinic. "Any field of life science that can put a video camera onto a microscope will begin to use image analysis," predicts Richard Cardullo, an associate professor of biology at the University of California, Riverside. In general, the technique acquires, digitizes, and then processes a microscope or scanned image, enhan
The Shape of Heredity
Susan M. Gasser | Jul 1, 2009 | 10+ min read
By Susan M. Gasser The Shape of Heredity Tracking the dance of DNA and structural proteins within the nucleus shows that placement makes the difference between gene activity and silence. What's true of the best architecture is also true of cellular structures: form follows function. We biologists often take this mantra to an extreme, searching for the function of a molecule or gene without much consideration of its structure, its phys
The Four R's
Amy Norton | Nov 21, 2004 | 7 min read
Teams at each of New York City's leading universities are making important research advances.

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