Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.
The finding confirms that a cluster of cells that directs the fate of other cells in the developing embryo is evolutionarily conserved across the animal kingdom.
Angie Voyles Askham, Spectrum | Feb 3, 2022 | 3 min read
The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.