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tag disease medicine limb development dna methylation menopause

Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
Detecting Tumors from Shed DNA
Douglas Steinberg | May 13, 2001 | 7 min read
Medical institutions across the United States will begin recruiting volunteers next month for a study that its investigators and outside observers describe as groundbreaking. They say it is the first large-scale trial to test the feasibility of using DNA shed by tumors to find early-stage cancer. During the three-year government-funded project, researchers will analyze DNA from stool samples to detect patterns characteristic of colorectal cancer (CRC). The study will have two other notable fe
diabetes complications type 2 biomarker blood test screen hydroxymethylation epigenetics cytosine
Blood-Based Epigenetic Screen Tests for Diabetes Complications
Katarina Zimmer | Oct 1, 2019 | 4 min read
Researchers could accurately detect life-threatening vascular complications in type 2 diabetes patients by analyzing hydroxymethylated cytosines in freely circulating DNA.
CRISPR Can Track Cellular History of a Mammalian Embryo
Sukanya Charuchandra | Aug 10, 2018 | 2 min read
Researchers used the genome-editing technology to analyze the development of mouse tissues.
Unmasking Secret Identities
Kate Yandell | Feb 1, 2014 | 9 min read
A tour of techniques for measuring DNA hydroxymethylation
Epigenetic Effects of Mom’s Diet
Emily Willingham | Apr 29, 2014 | 3 min read
Molecular markers of a mother’s nutrition around the time of conception can be found in her child’s DNA.
Recent Trials for Fragile X Syndrome Offer Hope
Randi Hagerman | Sep 1, 2019 | 10+ min read
Despite a solid understanding of the biological basis of fragile X syndrome, researchers have struggled to develop effective treatments.
How Some Vaccines Protect Against More than Their Targets
Shawna Williams | Nov 1, 2020 | 10+ min read
As researchers test existing vaccines for nonspecific protection against COVID-19, immunologists are working to understand how some inoculations protect against pathogens they weren’t designed to fend off.
Notebook
Steve Bunk | Nov 7, 1999 | 7 min read
Content Jumping DNA Semen pharming Screening for heart risk Real-time signaling PubSCIENCE starts, PubMedCentral grows When time stands still Shutting down the pump Brain gain JUMPING DNA Mutations aren't transmitted only by inheritance--they can cross species, too, according to recent findings by John F. McDonald, head of the genetics department at the University of Georgia (I.K. Jordan et al., "Evidence for the recent horizontal transfer of long terminal repeat retrotransposon," Proceedings of
Top Ten Innovations 2010
Megan Scudellari | Dec 1, 2010 | 10+ min read
By The Scientist Staff Top Ten Innovations 2010 Innovative products that have the life science community buzzing. As the global economy continues to pull out of its recent precipitous nosedive, one mantra rings true from Beijing to Boston—innovation can save us. If developing interesting new technologies and products really is the lifeblood of economic health, then the life sciences industry is innovation’s beating heart. The Scientist rec

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