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Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

disease & medicine, genetics & genomics, genetics

New Map Charts Genetic Expression Across Tissue Types, Sexes
Ashley Yeager | Sep 10, 2020 | 3 min read
A decade-long effort to probe gene regulation reveals differences between males and females, points to essential regulatory elements, and offers insight into past work on telomeres.
Long-Lasting Wound Infections Linked to Microbes and Genetics
Lisa Winter | Sep 1, 2020 | 2 min read
Two gene variations might help explain why some people experience chronic wounds.
gene, CRISPR, CRISPR-Cas9, gene editing, human embryo, chromosome, mutation, deletion
CRISPR Gene Editing Prompts Chaos in DNA of Human Embryos
Amanda Heidt | Jun 26, 2020 | 3 min read
Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.
Alzheimer’s Gene Linked to Higher Risk of Severe COVID-19
Jef Akst | May 26, 2020 | 2 min read
Two copies of the APOE4 variant, which confers a higher risk of dementia, doubles the risk of severe symptoms as a result of infection with SARS-CoV-2, according to a study.
Infographic: How Does Cell Senescence Drive Aging and Disease?
Katarina Zimmer | Mar 1, 2020 | 4 min read
The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.
Australian Lab Cultures New Coronavirus as Infections Climb
Jef Akst | Jan 29, 2020 | 2 min read
With more than 6,000 cases of the 2019-nCoV virus confirmed, researchers are hoping that studying the pathogen in the lab will help stop the outbreak.
China Sentences Gene-Editing Scientist to Three Years in Jail
Emily Makowski | Dec 30, 2019 | 2 min read
The modification of three babies’ genes by He Jiankui drew widespread criticism from scientists.
Circulating Fetal Cells Sequenced for Prenatal Testing Study
Emily Makowski | Dec 10, 2019 | 3 min read
Trophoblasts, collected from the mother during a blood draw, can determine fetal genetic abnormalities currently diagnosed through amniocentesis or chorionic villi sampling.
Error in Study Linking HIV Resistance Gene to Increased Mortality
Emily Makowski | Sep 30, 2019 | 2 min read
The authors have requested a retraction of a paper that found people with the CCR5 Δ32 variant are more likely to die sooner.
Recent Trials for Fragile X Syndrome Offer Hope
Randi Hagerman | Sep 1, 2019 | 10+ min read
Despite a solid understanding of the biological basis of fragile X syndrome, researchers have struggled to develop effective treatments.
Infographic: The Genetics of Fragile X Syndrome
Randi Hagerman | Sep 1, 2019 | 3 min read
Variation in the number of CGG repeats in the FMR1 gene at the bottom of the X chromosome can lead to increased levels of mRNA or decreased levels of protein—both conditions that cause disease.
feet on scale with tape measure
Genetic Study Points to Metabolic Roots of Anorexia Nervosa
Nicoletta Lanese | Jul 15, 2019 | 2 min read
Some variants implicated in the disease are also linked to other psychiatric disorders.
FDA Approves Gene Therapy for Spinal Muscular Atrophy
Ashley Yeager | May 27, 2019 | 3 min read
At $2 million for a single dose, Novartis’s Zolgensma is the most expensive medicine to date, but still less expensive over a lifetime than another approved drug for the rare genetic disease.
Allele Shows Pyrethroid Resistance’s Spread in African Mosquitos
Carolyn Wilke | Mar 22, 2019 | 4 min read
Researchers can now track the expansion of a resistance mechanism that allows the malaria vector Anopholes funestus to detoxify a key insecticide used on bed nets.
Lack of Diversity in Genetic Datasets is Risky for Treating Disease
Ashley Yeager | Mar 21, 2019 | 6 min read
Certain populations have been historically underrepresented in genome sequencing studies, but the NIH, private clinics, and 23andMe and other companies are trying to fix that.
Gene Drive–Equipped Mosquitoes Released into Lab Environment
Jef Akst | Feb 20, 2019 | 2 min read
The large-scale experiments aim to test how the technology would fare in the wild, if deployed to knock down populations of the pests.
AI App Identifies Rare Genetic Disorders from Photos of Patients’ Faces
Catherine Offord | Jan 8, 2019 | 2 min read
Deep-learning algorithms could help doctors narrow in on the causes of certain medical conditions, say researchers.
Babies’ Genomes Identify Risks Overlooked by Newborn Screens
Abby Olena, PhD | Jan 3, 2019 | 4 min read
A trial called BabySeq, in which researchers performed genomic sequencing on 159 newborns, identified children susceptible to diseases that regular screening doesn’t look for.
Claim of First Gene-Edited Babies Triggers Investigation
Catherine Offord | Nov 26, 2018 | 2 min read
He Jiankui says he has successfully used CRISPR-Cas9 to tweak the genes of twins born earlier this month. Some independent experts are dubious.
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