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tag c elegans genetics genomics drosophila disease medicine

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Group Unveils Worm's Complete Genetic Blueprint
Karen Hopkin | Jan 3, 1999 | 3 min read
December 10 marked another "major milestone" in molecular biology. An international consortium of scientists announced that they have obtained the first complete genetic blueprint of a complex animal. C. elegans Researchers from Washington University in St. Louis and the Sanger Centre in Cambridge, U.K., have sequenced the 97 million-base genome of Caenorhabditis elegans, biologists' favorite worm. The product of a nine-year effort, the C. elegans sequence joins those of E. coli and yeast in
Advances in the functional characterization of newly discovered microproteins hint at their diverse roles  in health and disease
The Dark Matter of the Human Proteome
Annie Rathore | Apr 1, 2019 | 10 min read
Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.
Bacteria and Humans Have Been Swapping DNA for Millennia
Kelly Robinson and Julie Dunning Hotopp | Oct 1, 2016 | 8 min read
Bacteria inhabit most tissues in the human body, and genes from some of these microbes have made their way to the human genome. Could this genetic transfer contribute to diseases such as cancer?
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
The Genetic Components of Rare Diseases
Kelly Rae Chi | Jul 1, 2016 | 9 min read
Techniques for determining which genes or genetic variants are truly detrimental
A fruit bat in the hands of a researcher
How an Early Warning Radar Could Prevent Future Pandemics
Amos Zeeberg, Undark | Feb 27, 2023 | 8 min read
Metagenomic sequencing can help detect unknown pathogens, but its widespread use faces challenges.
The Rodent Wars: Is a Rat Just a Big Mouse?
Ricki Lewis | Jul 4, 1999 | 5 min read
Sometimes it seems as if genome projects are cropping up everywhere.1 But until costs come down, limited resources are being largely concentrated into what Joseph Nadeau, professor of genetics at Case Western Reserve University School of Medicine, calls "the genome seven," an apples-and-oranges list of viruses, bacteria, fungi, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, and mouse, with Homo sapiens in its own category.2 Researchers widely acknowledge that in the rod
Expanding ENCODE
Jyoti Madhusoodanan | Aug 27, 2014 | 3 min read
Latest Encyclopedia of DNA Elements data enable researchers to compare genome regulation across species. 
Off-Target Effects Plague Drosophila RNAi
Jeffrey M. Perkel | Sep 10, 2006 | 3 min read
Two new studies suggest a major body of research may need to be reevaluated

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