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tag biochemistry developmental biology evolution cancer

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New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
Jason P. Dinh | Jul 1, 2022 | 4 min read
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
High-Tech Choir Master
Karen Hopkin | Jan 1, 2012 | 8 min read
Elaine Mardis can make DNA sequencers sing, generating genome data that shed light on evolution and disease.
Science's Rich Review Literature Charts The Evolution Of Disciplines
Ricki Lewis | Jan 21, 1996 | 8 min read
Of Disciplines Author: Ricki Lewis Sometimes in science, the best way to move forward is to take a long look backward. For discoveries and data to be put into context and used as springboards for future inquiry, investigators must periodically synthesize and reflect on what has been accomplished, and determine what remains to be learned. A review article is one way to chart the evolution of a scientific discipline. Science has a rich review literature. Of 3,383 journals surveyed in the 1994 Sc
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
The Cheating Amoeba
Gad Shaulsky | Jul 1, 2008 | 10+ min read
The Cheating Amoeba Scanning electron micrograph of spore towers of the slime mold Dictyostelium discoideum. David Scharf / Photo Researchers, Inc What genes contribute to social interactions such as cheating or altruism? And what could cheating genes tell us about sociality, multicellularity, and cancer? A social soil amoeba could hold the answers. By Gad Shaulsky Related Articles Infographic: Dictyostelium Developmental Cycle Video: Social activ
Contributors
Abby Olena, PhD | Mar 1, 2014 | 3 min read
Meet some of the people featured in the March 2014 issue of The Scientist.
The Human Genome
Arielle Emmett | Jul 23, 2000 | 10+ min read
Life sciences took center stage virtually around the world June 26. President Bill Clinton, flanked on the left by Celera Genomics Group president J. Craig Venter and on the right by National Human Genome Research Institute director Francis S. Collins, announced the completion of "the first survey of the entire human genome."
Forthcoming Books
The Scientist Staff | Nov 1, 1987 | 4 min read
ARCHAEOLOGY The Birth of Prehistoric Chronology: Dating Methods and Dating Systems In Nineteenth Century Scandinavian Archaeology. Bo Graslund. Cambridge University Press November, 150 pp, $39.50. Traces the origin and subsequent development of dating systems, examining how these systems grew and were improved and refined. BIOCHEMISTRY Biochemistry of Metabolism: Volume 11. David D. Davies, ed. Academic Press: November, 388 pp, $85. Discusses the metabolism of plants, emphasizing the b
RNA Calls the Shots
Ricki Lewis | Feb 23, 2003 | 6 min read
Courtesy of Vasudeva Mahavisno  CANCER CARTOGRAPHY: Metastatic prostate cancer from a tissue array stained for EZH2 protein. The background represents gene expression signatures of prostate cancer as a heat map, which lead to the discovery of EZH2 as a prostate cancer biomarker. As soon as Watson and Crick deduced DNA's structure half a century ago, their thoughts turned to RNA. Arguably the most important molecule in the living world, RNA not only connects gene to protein, but its catal

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