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image: Getting Back in Shape

Getting Back in Shape

By | December 1, 2015

Contrary to years of research suggesting otherwise, most aggregated proteins regain their shape and functionality following heat shock.

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image: Adding Padding

Adding Padding

By | November 1, 2015

Adipogenesis in mice has alternating genetic requirements throughout the animals’ lives.

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image: Fanning the Flames

Fanning the Flames

By | November 1, 2015

Obesity triggers a fatty acid synthesis pathway, which in turn helps drive T cell differentiation and inflammation.

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image: Brain Freeze

Brain Freeze

By | October 1, 2015

A common tissue fixation method distorts the true neuronal landscape.

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image: Hearing Discrepancy Probed

Hearing Discrepancy Probed

By | September 1, 2015

Common in vitro experiments have distorted the true mechanics of mammalian hair cell stereocilia.

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image: Inner Ear Undertakers

Inner Ear Undertakers

By | September 1, 2015

Support cells in the inner ear respond differently to two drugs that kill hair cells.

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image: The Regenerators

The Regenerators

By | September 1, 2015

A molecular signature makes it possible to trace the details of hair cell replacement in the mammalian inner ear.

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image: Signaling Resistance

Signaling Resistance

By | April 1, 2015

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.

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image: Toggling Between Life and Death

Toggling Between Life and Death

By | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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image: Growth Hormone Guidance

Growth Hormone Guidance

By | March 1, 2015

Intact growth hormone signaling pathways are needed for methionine restriction to extend mouse lifespan.

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