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antibody validation reproducibility crisis C9ORF72
Opinion: Scientists Need to Demand Better Antibody Validation
My lab has developed a protocol to easily assess the specificity of antibodies—and hopefully stem some of the reproducibility crisis.
Opinion: Scientists Need to Demand Better Antibody Validation
Opinion: Scientists Need to Demand Better Antibody Validation

My lab has developed a protocol to easily assess the specificity of antibodies—and hopefully stem some of the reproducibility crisis.

My lab has developed a protocol to easily assess the specificity of antibodies—and hopefully stem some of the reproducibility crisis.

techniques, opinion

longevity prediction estimate lifespan methylation telomere biomarkers eldely old age centenarian
Opinion: Biomarkers of Longevity Not Ready for the Clinic
John D. Loike and Ruth L. Fischbach | Sep 27, 2019 | 4 min read
The science isn’t there yet, nor are the known interventions that ought to be combined with delivering such predictions.
xenotransplantation organ transplant donor shortage organoid stem cell chimera ethics bioethics
Opinion: Develop Organoids, Not Chimeras, for Transplantation
John D. Loike and Robert Pollack | Aug 23, 2019 | 4 min read
Scientists are devising human-animal hybrids for harvesting human organs, but lab-derived mini-organs are a less ethically fraught solution to meeting the need for transplantation.
brain activity brainex perfusion
Opinion: Test Brain-Reviving Technology in Infants First
John D. Loike and Alan Kadish | Jul 9, 2019 | 3 min read
If a system tested in decapitated pigs ever gets to human clinical trials, neuroscientific and ethical reasons point to testing babies before adults.
artificial intelligence ai synthetic nucleotides what is life definition of life
Opinion: How to Define Life
John D. Loike and Robert Pollack | May 2, 2019 | 3 min read
As artificial life forms become more sophisticated, we propose a simple list of criteria to determine whether synthetic biological organisms and robots are living beings.
Opinion: The New Frontiers of Epigenetics
John D. Loike | Nov 12, 2018 | 3 min read
Newly developed techniques could propel a field already advancing rapidly to complement modern medicine.
Opinion: No, AI Will Not Replace Radiologists
Phil Shaffer | Jul 17, 2018 | 4 min read
The adoption of machine-learning techniques to aid in diagnosis should be done with radiologists’ guidance.
Opinion: Deductive Science Is Needed for Public Health
Giuseppe Carruba | Jun 27, 2018 | 3 min read
Big data and empirical approaches to understanding diseases provide a limited picture of pathogenesis.
Opinion: Rise of the Robot Radiologists
Mutaz Musa | Jun 25, 2018 | 4 min read
The first wave of AI-driven job loss among doctors will be in the field of radiology and is poised to force a paradigm shift in medical imaging.
Opinion: How to Use Mobile Apps for Immunohistochemistry
Alexander E. Kalyuzhny | May 25, 2018 | 4 min read
This guide for apps comes from personal experience testing various programs aimed to improve productivity or to help with selecting reagents.
Opinion: Should Human-Animal Chimeras Be Granted “Personhood”?
John D. Loike | May 23, 2018 | 4 min read
Determining which products of advanced biotechnology are deserving of legal protections is essential to our own social architecture.
Opinion: Missing Methods
Irwin H. Gelman | May 3, 2012 | 4 min read
A lack of methodological detail in the published literature threatens the foundation of scientific discourse.
Opinion: Thinking Outside the Genome
Stephen Friend | Oct 1, 2011 | 4 min read
By extending its reach beyond science, the field of omics will change the way we live our lives.
At the Tipping Point
H. Steven Wiley | Feb 1, 2011 | 3 min read
Data standards need to be introduced—now.
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