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tag cell molecular biology pcr mass spectrometry biomarkers disease medicine

a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker, PhD | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
A Revolutionary Approach to Biomarker Discovery
Emanuel F. Petricoin and Lance A. Liotta | Nov 1, 2006 | 10+ min read
A Revolutionary Approach to Biomarker Discovery Immunoassays coupled with mass spectrometrycould reveal new dimensions in the blood  By Emanuel F. Petricoin and Lance A. Liotta ARTICLE EXTRAS Proteomics: Promise and ProblemsSuch early disease detection doesn't always mean longer life, write JENNIFER MILLER and BARNETT KRAMER. INFOGRAPHIC: The Peptidome Hypothesis:What does a disease signature look like in the blood? Serum Proteomics ScrutinizedSELDI-TOF st
Innovations Expand Lab Power, Uses Of PCR Technique
Ricki Lewis | Jul 25, 1993 | 8 min read
The gene amplification technique invented by genetics researcher Kary Mullis on a moonlit drive through the northern California hills a decade ago--the polymerase chain reaction (PCR)-- continues to revolutionize the life sciences. Uses in molecular biology research and in diagnostic tests are proliferating, and PCR is even bringing a new molecular approach to such fields as paleontology and epidemiology. The following companies are among those supplying PCR-related products for the resear
Quantitating Glycans for Biomarker Discovery
Amanda Keener | Aug 27, 2017 | 8 min read
Techniques for comparing the relative abundances of glycans and glycoproteins in clinical samples
A Comprehensive Guide to Proteomics
An Introductory Guide to Proteomics
Sejal Davla, PhD | Jan 16, 2023 | 5 min read
Deconstructing concepts, approaches, and data analysis in proteomics workflows.  
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Vital Signs
Kelly Rae Chi | Apr 1, 2011 | 7 min read
New frontiers in the search for novel, noninvasive biomarkers
SPRead Your Antibody Capabilities
Carina Storrs | May 1, 2012 | 8 min read
Using surface plasmon resonance to improve antibody detection and characterization: four case studies
PCR Primed To Spur Chain Of Applications
Holly Ahern | Jun 25, 1995 | 10+ min read
What would you do if your research interests revolved around obtaining DNA from a bacterium preserved for millions of years in the gut of a bee stuck in amber, matching up a murderer to crime- scene blood half a century old, or cloning genes from a 1,000- year-old mummy? Most scientists would first consider PCR--the polymerase chain reaction--as a technique for approaching problems such as these. With PCR, minute quantities of nucleic acids can be amplified millions of times into sufficient qua

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