By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.
In addition to isolating the first protein-coding gene from a eukaryote, Kedes furthered scientists’ understanding of actin genes and also laid the foundations for modern DNA databases such as GenBank.
A mutant protein called Siglec-XII may promote carcinoma progression in humans, but inactivation of its gene seems to avoid the problem, according to a study.
A physician and neurobiologist at the Rockefeller University who specialized in addiction research, Kreek was best known for her work on developing the treatment for heroin addiction.
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.
Alejandra Manjarrez, PhD | Feb 8, 2021 | 4 min read
While studying a degenerative eye disease, researchers find the first evidence that cells produce endogenous DNA in the cytoplasm. Drugs that block this activity are linked with reduced risk of atrophic age-related macular degeneration.