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Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

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image: Screening  with CRISPR

Screening with CRISPR

By | June 1, 2016

Ever-improving CRISPR-based tools are already ripe for large-scale genetic screens.

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image: Pulling It All Together

Pulling It All Together

By | April 1, 2016

Systems-biology approaches offer new strategies for finding hard-to-identify drug targets for cancer.

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image: Cracking the Complex

Cracking the Complex

By | November 1, 2015

Using mass spec to study protein-protein interactions

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image: In Custody

In Custody

By | April 1, 2015

Expert tips for isolating and culturing cancer stem cells

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image: Surviving the Ice Age

Surviving the Ice Age

By | September 1, 2014

A beginner’s guide to freezing and thawing pluripotent stem cells

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image: Tailoring Your Proteome View

Tailoring Your Proteome View

By | August 1, 2014

Computational tools can streamline the development of targeted proteomics experiments.  

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image: Bird’s-Eye Proteomics

Bird’s-Eye Proteomics

By | July 1, 2014

A guide to mass spectrometers that can handle the top-down-proteomics challenge

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image: Moving Target

Moving Target

By | June 1, 2014

New mass spectrometry–based techniques are blurring the lines between discovery and targeted proteomics.

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image: Capturing Cancer Cells on the Move

Capturing Cancer Cells on the Move

By | April 1, 2014

Three approaches for isolating and characterizing rare tumor cells circulating in the bloodstream

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