microscopy, techniques

The chemist and biophysicist won a Nobel prize for the development of a technique to probe the structures of nucleotide-protein complexes.

This year’s winners also include the developers of nusinersen, an oligonucleotide therapeutic for spinal muscular atrophy.

The Nikon photomicrography competition winners of 2018 include striking close-ups of a compound eye, a fern, and an insect’s bubble house.

Lineage tracing reveals how cells help the salamanders regrow chopped-off limbs.

The winner of the 2018 Nikon Small World in Motion video competition shows the development of sensory neurons in a zebrafish embryo.

Researchers have updated a method to look at biochemical activities inside living cells.

An open-source microscopy method can super-resolve live cells even under low lighting.

With open-source software and Lego hardware, researchers have created a low-cost, automated method for cellular fluorescence microscopy.

By combining two microscopy techniques, researchers produce images of structures less than 10 nanometers wide.

Chemistry Nobel goes to Jacques Dubochet, Joachim Frank, and Richard Henderson. 

To improve the resolution of biological samples at the cellular level, researchers inflate tissues with “swellable polymers” so that they’re easier to see under the microscope.    

A double-expansion technique embeds brain tissue in the absorbent material of diapers to stretch out cells for easier visualization.

How to make the most of this rapidly developing technique and a look at what's on the horizon

Celebrating 30 years and a resurrection

From confocal fluorescence microscopy to super-resolution and live 3-D imaging, microscopes have changed rapidly since 1986.

Since The Scientist published its first issue in October 1986, life-science research has transformed from a manual and often tedious task to a high-tech, largely automated process of unprecedented efficiency.

“Ultimate DISCO” uses a solvent that shrinks whole animals and preserves fluorescence for months.

The Scientist’s choice of major improvements in imaging, optogenetics, single-cell analyses, and CRISPR

Modifying a vibration-based optical technique can capture images of living tissues, researchers show.