genetics & genomics, cell & molecular biology, genetics

The announcement by Novartis, the maker of Zolgensma, has drawn mixed reactions from the spinal muscular atrophy community.

Trophoblasts, collected from the mother during a blood draw, can determine fetal genetic abnormalities currently diagnosed through amniocentesis or chorionic villi sampling.

Cardiomyocytes made from iPSCs aboard the International Space Station had upregulated mitochondrial functioning.

Researchers treat mice with retinitis pigmentosa using a gene therapy that reduces cone loss.

Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.

Viruses that infect plants and occasionally insects appear to cause infection with a divide-and-conquer strategy, multiplying separate segments of genetic material in different host cells.

A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.

A study on yeast illuminates how insertions may occur.

This could account for some reproducibility problems in cell line research, according to the authors of a comprehensive analysis of HeLa variants.

Two studies contest the idea that the noncoding sequences are just “junk DNA,” demonstrating that they play important roles in the regulation of cell growth.

Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.

Scientists at the Allen Institute for Cell Science have developed an open-source stem cell line with fluorescent tags for cardiac cells.

An entrepreneurial attitude helped this Vienna-based researcher begin to unravel the complex receptor network that Arabidopsis uses to develop and defend itself.

With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.

New starring roles for nucleic acids

The cell-surface receptor, SIRP-alpha, initiates the innate immune response in hosts.  

The Yale University cell and molecular biologist is probing the deep mysteries of epidermal cells.

Researchers repurpose a bacterial immune system to be a molecular recording device.

Elaine Fuchs has worked on adult stem cells since before they were so named, figuring out how multipotent epidermal cells renew or turn into skin or hair follicles.