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3D Rendering of Molecular Interaction in CAR Chimeric Antigen Receptor
Next-generation CAR and TCR Cancer Therapies
Danielle Gerhard, PhD | Mar 15, 2024 | 10+ min read
From smart receptors to novel biologics, scientists plan to overcome the challenges of treating solid tumors.
A needle drawing up fluid from an unlabeled vial.
Cancer Vaccination as a Promising New Treatment Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 10+ min read
Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.
Epigenetic Influences and Mechanisms in Cancer
Epigenetic Influences and Mechanisms in Cancer
The Scientist Staff | 1 min read
In this webinar, Özgen Deniz and Christina Leslie will discuss how epigenetic regulation affects oncogenesis.
Robot hand holding glass sphere with glowing fiber neon communication wires
Gazing into Science’s Crystal Ball
Meenakshi Prabhune, PhD | Mar 15, 2024 | 3 min read
Basic research successes offer glimpses into future scientific advancements, but the outcomes are subject to change.
3D outline of a bone with red dots in the center.
Bringing Immunotherapy Straight to the Source
Aparna Nathan, PhD | Mar 14, 2024 | 4 min read
Engineered natural killer cells track down cancer cells in the bone marrow.
An Overview of High Throughput Screening
An Overview of High Throughput Screening
Tanvir Khan, PhD | 5 min read
High throughput screening (HTS) relies on liquid handling devices, robotics, plate readers, and data processing software to automatically test a large number of biological, genetic, chemical, or pharmacological samples. 
3D illustration of a lymphocyte in white and green.
A Quest for the Holy Grail of Cancer Targets
Danielle Gerhard, PhD | Mar 14, 2024 | 5 min read
Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.
Magnifying glass over a DNA sequence
A Science Sleuth Accuses a Harvard Medical School Neuroscientist of Research Misconduct
Danielle Gerhard, PhD | Feb 15, 2024 | 5 min read
Researchers await the outcome of an ongoing investigation into dozens of instances of alleged image problems spanning 29 publications over a period of 23 years.
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Hijacking Viruses: Optimizing Lentivirus-Based Cell Engineering
The Scientist | 1 min read
Filippo Rossignoli discusses the challenges he faced when employing lentiviruses to produce immunotherapies and how he overcame these obstacles.
Toppling the Genetic Dominoes in Bone Metastasis
Laura Tran, PhD | Feb 15, 2024 | 4 min read
A key gene that fuels the molecular cascade driving prostate cancer bone metastasis progression may open avenues for targeted therapies.
3D rendered image showing enhanced scanning electron micrograph of cancer cells.
Turning Off Metastasis in Breast Cancer
Nathan Ni, PhD | Feb 13, 2024 | 4 min read
An on-off enzyme switch controls metastasis in mice. 
<h1 >Precision Medicine: A New Era in Cancer Therapy</h1>
Precision Medicine: A New Era in Cancer Therapy
Rebecca Roberts, PhD | 6 min read
Precision medicine helps clinicians tailor individual treatments, addressing genetic mutations, tumor microenvironment variations, and therapeutic resistance.
All Roads Lead to Genome Editing
Danielle Gerhard, PhD | Feb 9, 2024 | 6 min read
Shondra Pruett-Miller has taken many paths in her career with her love of genome editing always as a guiding light.
A Master Regulator of Gene Expression
Mariella Bodemeier Loayza Careaga, PhD | Jan 31, 2024 | 4 min read
A CRISPR-based screening platform helped scientists identify a transcription factor that makes CAR T cells better at killing cancer cells. 
TSS
The Art and Science of Synthetic Biology 
The Scientist | 2 min read
Researchers get creative using bacterial bits and pieces to produce synthetic cells for studying cancer.
Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Advanced Spatial Tools Map Hematopoietic Stem Cell Niches
Niki Spahich, PhD | Jan 15, 2024 | 4 min read
New technologies and archival tissue biopsy samples enable exploration of changes in the bone marrow as people age.
Aging and Cancer
Aging and Cancer
Rebecca Roberts, PhD | 6 min read
The relationship between aging and cancer is complex, with several shared underlying mechanisms. 
Hijacking Neurons’ Adaptive Abilities
Shelby Bradford, PhD | Jan 3, 2024 | 3 min read
Brain tumors use the brain’s plasticity to promote their own growth.
A syringe delivering a fleet of DNA nanorobots to a cancer cell.
Building Biomolecular Machines
Danielle Gerhard, PhD | Jan 1, 2024 | 2 min read
William Shih draws inspiration from origami and jigsaw puzzles in his quest to build bigger DNA nanorobots.
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