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tag techniques microbiology electron microscopy neuroscience

This image depicts the fruit fly nerve cord connectome. It highlights 930 neurons, a subset of the full set of reconstructed neurons.
The Expansion of Volume Electron Microscopy
Danielle Gerhard, PhD | Sep 8, 2023 | 6 min read
A series of technological advancements for automation and parallel imaging made volume electron microscopy more user friendly while increasing throughput.
Charting a New Course Through the Injured Brain
Rashmi Shivni | Jan 15, 2024 | 4 min read
A state-of-the-art technique helps scientists map out tissue at the single cell level after a demyelinating brain injury.
An illustration of a flask of bacteria, a weighted microscope slide, and two bacteria exchanging materials via nanotubes.
Infographic: Sources of Variation in Bacterial Nanotube Studies
Sruthi S. Balakrishnan | Jun 1, 2021 | 2 min read
Differences in how researchers prepare and image samples can lead to discrepancies in their results.
A scanning electron micrograph of a coculture of E. coli and Acinetobacter baylyi. Nanotubes can be seen extending from the E. coli.
What’s the Deal with Bacterial Nanotubes?
Sruthi S. Balakrishnan | Jun 1, 2021 | 10+ min read
Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?
New Technique Captures Entire Fly Brain in 3D
Carolyn Wilke | Jan 18, 2019 | 2 min read
The method combines two approaches to reveal a high-resolution map of all 40 million synapses.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Imaging Chromatin to Deduce Function from Form
Marissa Fessenden | Dec 1, 2018 | 7 min read
Researchers describe their tools for probing how the physical shape of the genome affects genes’ function.
Arsenic and Old Protein Labels
Brendan Maher | May 26, 2002 | 2 min read
For a team at the University of California, San Diego, nine years of tinkering with arsenic paid off in the development of a new technique that can tag proteins with different colors over time and even zero in to electron microscopic resolution. Roger Tsien, Howard Hughes Medical Institute investigator and professor of pharmacology, chemistry, and biochemistry at UCSD, says the project started with the suggestion from a colleague that one can tag a two-cysteine sequence in a protein with a singl

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