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tag gene silencing genetics genomics cancer modus operandi

A fishing cat with a fish in its mouth
Genome Spotlight: Fishing cat (Prionailurus viverrinus)
Christie Wilcox, PhD | Dec 22, 2022 | 5 min read
A high-quality reference genome for this vulnerable feline may help scientists understand why they’re so prone to transitional cell carcinoma in captivity.
Telomeres as the Key to Cancer
Jeffrey Perkel | May 26, 2002 | 9 min read
The standard modus operandi for modeling human diseases in the mouse: Find an interesting gene, knock it out, and watch what happens. In theory, the approach makes perfect sense, and scientists have obtained countless subtle insights into the complexities of biology because of it. But mice, of course, are not humans, and many investigators have had to hastily rewrite otherwise elegant theories because of mouse data. One reason? Researchers have taken for granted that telomere length matters. But
an artistic rendering of CRISPR/Cas9
Ten Years of CRISPR
Sophie Fessl, PhD | Jun 28, 2022 | 7 min read
This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.
Karyotype with most chromosomes in blue, one in red and green. 
Researchers Fuse Mouse Chromosomes in Scientific First
Natalia Mesa, PhD | Aug 25, 2022 | 4 min read
The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.
Enzyme Role Found for Aging Gene
Jennifer Fisher Wilson | Nov 10, 2002 | 6 min read
Graphic: Courtesy of Shin-Ichiro Imai  SILENCE OF THE CHROMATIN: The Sir2 protein requires NAD for its enzymatic activity. It couples NAD breakdown to nicotinamide and ADP-ribose with the removal of acetyl groups from histone and other proteins. The acetyl moiety is transferred to ADP-ribose, which creates the chemical acetyl-ADP ribose. Deacetylated nucleosome are packed up to silenced chromatin structure and involved in silencing gene transcription. This Sir2 enzymatic activity links ene
Image shows photorhabdus virulence cassettes (green) binding to insect cells (blue) prior to injection of payload proteins. 
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells
Rohini Subrahmanyam, PhD | Apr 20, 2023 | 4 min read
Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.
Genome Economy
Ricki Lewis | Jun 10, 2001 | 10 min read
The Human Genome Project's discovery1 that the human body runs on an instruction manual of a mere 35,000 or so genes--compared to the worm's 19,000, the fruit fly's 13,000, and the tiny mustard relative Arabidopsis thaliana's 25,000--placed humanity on an even playing field with these other, supposedly simpler, organisms. It was a humbling experience, but humility quickly gave way to awe with the realization that the human genome might encode 100,000 to 200,000 proteins. Scientists base this num
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Epigenetics: Genome, Meet Your Environment
Leslie Pray | Jul 4, 2004 | 10+ min read
©Mehau Kulyk/Photo Researchers, IncToward the end of World War II, a German-imposed food embargo in western Holland – a densely populated area already suffering from scarce food supplies, ruined agricultural lands, and the onset of an unusually harsh winter – led to the death by starvation of some 30,000 people. Detailed birth records collected during that so-called Dutch Hunger Winter have provided scientists with useful data for analyzing the long-term health effects of prenat
The Right Sort
Richard P. Grant | Aug 1, 2011 | 3 min read
Using the strongest molecular binding partnership in biology to separate different cell types.

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