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tag cancer microbiology gene silencing

Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
A needle drawing up fluid from an unlabeled vial.
Cancer Vaccination as a Promising New Treatment Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 10+ min read
Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.
Silencing Cancer
Jack Lucentini | Sep 12, 2004 | 6 min read
DELIVERY METHODS:© 2003, Elsevier ScienceSmall interfering RNAs (siRNAs) may be synthesized and then transfected into cells (A), or generated by the RNAase activity of Dicer (B) on short hairpin RNAs (shRNAs) transcribed in vivo (C). Transfection (D) and integration (E) of plasmid DNA containing a selectable marker and a promoter to drive shRNA expression are used to generate a stable cell line. Alternatively, DNA encoding shRNA may be introduced by viral-mediated transduction (D). siRNAs (
Illustration showing the upper part of a human body connected to a DNA helix
Unraveling the Mystery of Zombie Genes
Iris Kulbatski, PhD | Oct 31, 2023 | 6 min read
Digging into how and why some genes are resurrected after death sounds morbid, but it has practical applications. 
Gene Silencing Is Golden
Carina Storrs | Aug 1, 2013 | 9 min read
A beginner’s how-to on RNAi screening in mammalian cells
How ubiquitin silences genes
Cathy Holding(cathyholding@absw.org.uk) | Nov 7, 2004 | 3 min read
Study uncovers mechanism of histone monoubiquitylation and gene silencing
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
Unsilencing a Gene
Tia Ghose | Dec 21, 2011 | 3 min read
Scientists have found a way to reactivate a gene in mice that is silenced in a neurodevelopmental disorder called Angelman syndrome.
Prominent Epigeneticist Dies
Bob Grant | Mar 7, 2017 | 1 min read
The National Cancer Institute’s Amar Klar uncovered many of the intricacies of gene silencing and other heritable epigenetic alterations.
Enzyme Role Found for Aging Gene
Jennifer Fisher Wilson | Nov 10, 2002 | 6 min read
Graphic: Courtesy of Shin-Ichiro Imai  SILENCE OF THE CHROMATIN: The Sir2 protein requires NAD for its enzymatic activity. It couples NAD breakdown to nicotinamide and ADP-ribose with the removal of acetyl groups from histone and other proteins. The acetyl moiety is transferred to ADP-ribose, which creates the chemical acetyl-ADP ribose. Deacetylated nucleosome are packed up to silenced chromatin structure and involved in silencing gene transcription. This Sir2 enzymatic activity links ene

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