genetics & genomics, Modus Operandi

By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.

Integrating a specialized histone into large segments of transgenic DNA enables centromere formation.

Recruiting an epigenetic instigator of centromere formation into large segments of cloned DNA facilitates their transformation into artificial chromosomes.

Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.

A CRISPR-based electronic sensor flags target DNA sequences at high speed.

Scientists combine CRISPR gene editing with single-cell sequencing for genotype-phenotype screens.

See how two new methods track responses to unique genetic manipulations in numerous individual cells in parallel.

A test tube-based genome-labeling technique has been brought under the microscope.

Researchers have designed a screen to find unique molecules, called riboswitches, that determine whether transcription will proceed.

A versatile modular strategy for detecting small molecules in eukaryotes

Tailored combinations of a reporter and a ligand-binding domain allow for sensing just about any molecule of interest.

Scientists perform plant-genome modifications on crops without using plasmids.