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tag techniques gene silencing cancer

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Delivering Silence
Sabrina Richards | Mar 1, 2012 | 2 min read
Using RNA viruses to silence genes could optimize tissue targeting while reducing toxicity.
Blue 3D illustration of X-shaped chromosomes
X Chromosome Silenced in Some Cancers in Males
Natalia Mesa, PhD | Nov 11, 2022 | 3 min read
A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 
Silencing Cancer
Jack Lucentini | Sep 12, 2004 | 6 min read
DELIVERY METHODS:© 2003, Elsevier ScienceSmall interfering RNAs (siRNAs) may be synthesized and then transfected into cells (A), or generated by the RNAase activity of Dicer (B) on short hairpin RNAs (shRNAs) transcribed in vivo (C). Transfection (D) and integration (E) of plasmid DNA containing a selectable marker and a promoter to drive shRNA expression are used to generate a stable cell line. Alternatively, DNA encoding shRNA may be introduced by viral-mediated transduction (D). siRNAs (
Gene Silencing Is Golden
Carina Storrs | Aug 1, 2013 | 9 min read
A beginner’s how-to on RNAi screening in mammalian cells
electron micrograph of grey cancer cell, with two red T cells stuck to the side
Translation of “Jumping Genes” Creates Cancer Therapy Targets
Natalia Mesa, PhD | Mar 29, 2023 | 4 min read
Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.
The Complexity of Gene Silencing
Jim Kling | Feb 17, 2002 | 6 min read
For this article, Jim Kling interviewed University of Edinburgh geneticist Adrian Bird and Paul A. Wade, assistant professor in the department of pathology and laboratory medicine at Emory University School of Medicine in Atlanta. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. H.-H. Ng, Y. Zhang, B. Hendrich, C.A. Johnson et al., "MBD2 is a transcriptional repressor belonging to the MeCP
Characterizing the Imprintome
Amber Dance | Jan 1, 2017 | 8 min read
Three techniques for identifying the collection of maternal and paternal genes silenced in offspring
Shhh: Silencing Genes with RNA Interference
Gail Dutton | Apr 6, 2003 | 8 min read
 TECHNICAL KNOCKOUT: A Cy3-labeled siRNA targeting B-actin was transfected into HeLa cells and protein expression was analyzed 96-hours later. Red, Cy3-labeled siRNA; Blue: DAPI-stained nuclei; Green, B-actin protein. (siRNA was prepared and labeled using Ambion's Silencer siRNA construction kit and labeling kit, respectively). RNA interference, or RNAi, is all the rage these days. According to the Web of Science database (ISI, Philadelphia), the number of articles on the topic jumped fr
The Second Coming of RNAi
Eric Bender | Sep 1, 2014 | 10+ min read
Now showing clinical progress against liver diseases, the gene-silencing technique begins to fulfill some of its promises.

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