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tag physiology cell molecular biology inflammation insulin

A Molecular Switch for Bone Loss
Mariella Bodemeier Loayza Careaga, PhD | Jan 23, 2024 | 4 min read
Blocking an abnormally active signaling pathway in skeletal stem and progenitor cells alleviates bone mass decline in middle-aged mice. 
Molecular Biology
The Scientist Staff | Apr 4, 1993 | 2 min read
S. Shimasaki, L. Gao, M. Shimonaka, N.Ling, "Isolation and molecular cloning of insulin-like growth factor-binding protein- 6," Molecular Endocrinology, 5:938, 1991. Shunichi Shimasaki (Whittier Institute for Diabetes and Endocrinology, La Jolla, Calif.): "There are two types of insulin-like growth factors: IGF-I and IGF-II, which act on a wide variety of target cells to regulate growth and cytodifferentiation. The IGF ligands interact with plasma membrane receptors, and the interactions are
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Peripheral blood mononuclear cells surrounded by red blood cells in circulating blood.
Accelerating Immune Research with Cryopreserved Peripheral Blood Mononuclear Cells
The Scientist and MilliporeSigma | Jul 18, 2022 | 3 min read
Commerically-available peripheral blood mononuclear cells offer a well-characterized, accessible, and consistent model for immunology and therapeutic development.
A 3D medical illustration of a human heart with a cardiogram in the foreground and a blue background that includes DNA helices.
Connecting the Complexities of Heart Failure and Aging
Deanna MacNeil, PhD | Feb 13, 2023 | 3 min read
Researchers learned how IGFBP7, a senescence signaling protein and biomarker, promotes cardiac remodeling and cellular aging.
A close up of several modular puzzle pieces.
Making Connections: Click Chemistry and Bioorthogonal Chemistry
Deanna MacNeil, PhD | Feb 13, 2024 | 5 min read
Simple, quick, and modular reactions allow researchers to create useful molecular structures from a wide range of substrates.
Senior woman wearing a grey pullover sitting on a bed and holding her back.
Early Inflammation Protects Against Chronic Pain, Study Finds
Alejandra Manjarrez, PhD | May 12, 2022 | 3 min read
Human data and experiments in mice challenge the common use of anti-inflammatory drugs to treat pain.
Aging and Cancer
Aging and Cancer
Rebecca Roberts, PhD | Nov 14, 2023 | 6 min read
The relationship between aging and cancer is complex, with several shared underlying mechanisms. 
Conceptual illustration of cells releasing cytokines in various shades of blue
Spleen-to-Liver Signals Control Systemic Inflammation
Ruth Williams | Apr 29, 2021 | 3 min read
In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.
Molecular Biology
The Scientist Staff | Jun 7, 1992 | 2 min read
S. Akira, T. Hirano, T. Taga, T. Kishimoto, "Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)," FASEB Journal, 4:2860-67, 1990. Shizuo Akira (Institute for Molecular and Cellular Biology, Osaka University, Japan): "Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a central role in defense mechanisms, including the immune response, acute phase reaction, and hematopoiesis. Since our success in the cloning of the IL-6 cDNA in 1985, our group has been study

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